| RRC ID |
1157
|
| 著者 |
Unno H, Kamei K, Honda A, Nishimura K, Kuriyama T.
|
| タイトル |
A murine model of pulmonary basidiomycosis by Schizophyllum commune.
|
| ジャーナル |
J Infect Chemother
|
| Abstract |
Schizophyllum commune has recently emerged as a causative agent of human mycosis, but the details of its virulence are not yet known. To elucidate the pathogenicity of S. commune, a murine model of invasive pulmonary infection was established. ICR mice, not immunosuppressed or immunosuppressed by cortisone acetate, were infected with S. commune by intratracheal inoculation with agar beads containing the basidiospores. All immunosuppressed mice died within 2 weeks. Pathology examination revealed massive mycelial invasion into the lungs, penetration into adjacent vessels, and systemic dissemination, suggesting much higher virulence of this fungus than was previously estimated. This is the first murine model of pulmonary infection by S. commune, which we believe can be of assistance during subsequent investigations of this infection.
|
| 巻・号 |
11(3)
|
| ページ |
136-40
|
| 公開日 |
2005-6-1
|
| DOI |
10.1007/s10156-005-0382-2
|
| PII |
S1341-321X(05)70996-X
|
| PMID |
15990977
|
| MeSH |
Animals
Blood Vessels / microbiology
Blood Vessels / pathology
Disease Models, Animal
Female
Immunocompromised Host
Lung / blood supply
Lung / microbiology
Lung / pathology
Lung Diseases, Fungal / immunology
Lung Diseases, Fungal / microbiology
Lung Diseases, Fungal / pathology*
Mice
Mice, Inbred ICR
Schizophyllum*
|
| IF |
1.722
|
| リソース情報 |
| 病原微生物 |
IFM 47009 |
