RRC ID 1159
Author Teixeira AB, Silva M, Lyra L, Luz EA, Uno J, Takada H, Miyaji M, Nishimura K, Schreiber AZ.
Title Antifungal susceptibility and pathogenic potential of environmental isolated filamentous fungi compared with colonizing agents in immunocompromised patients.
Journal Mycopathologia
Abstract Infection is a major cause of morbidity and mortality in bone marrow transplant recipients and in patients with hematological malignancies. The source of infection is almost always endogenous flora or the hospital environment. The present study evaluated bone marrow transplant recipients and patients with hematological malignancies colonized and/or infected with filamentous fungi. During 1 year, environmental air samples were also taken from the bone marrow transplant unit by a modification of gravity air-setting plate (GASP) methodology. Fusarium spp. were the most prevalent genus in the fall and Cladosporium spp. in the winter. Clinically isolated strains grew better at 37 degrees C than environmental strains. According to NCCLS M-38P methods, environmental Aspergillus strains showed higher MICs to miconazol and itraconazol, and clinical Fusarium strains were less susceptible to fluconazole.
Volume 160(2)
Pages 129-35
Published 2005-9
DOI 10.1007/s11046-005-0117-z
PMID 16170608
MeSH Air Microbiology* Antifungal Agents / pharmacology* Aspergillus / drug effects Aspergillus / isolation & purification Aspergillus / pathogenicity Bone Marrow Transplantation / adverse effects Cladosporium / drug effects Cladosporium / isolation & purification Cladosporium / pathogenicity Fusarium / drug effects Fusarium / isolation & purification Fusarium / pathogenicity Hematologic Neoplasms / complications Hospitals, Teaching Humans Immunocompromised Host* Microbial Sensitivity Tests Mitosporic Fungi / classification Mitosporic Fungi / drug effects* Mitosporic Fungi / isolation & purification Mitosporic Fungi / pathogenicity* Mycoses / microbiology*
IF 2.278
Times Cited 7
Pathogenic microorganisms IFM 5774 IFM 40205 IFM 46829 Fusarium spp. ? Cladosporium spp.? Aspergillus?