論文 - 詳細
| RRC ID | 11646 |
|---|---|
| 著者 | Zhang H, Liu J, Li CR, Momen B, Kohanski RA, Pick L. |
| タイトル | Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Insulin/Insulin-like growth factor signaling regulates homeostasis and growth in mammals, and is implicated in diseases from diabetes to cancer. In Drosophila melanogaster, as in other invertebrates, multiple Insulin-Like Peptides (DILPs) are encoded by a family of related genes. To assess DILPs' physiological roles, we generated small deficiencies that uncover single or multiple dilps, generating genetic loss-of-function mutations. Deletion of dilps1-5 generated homozygotes that are small, severely growth-delayed, and poorly viable and fertile. These animals display reduced metabolic activity, decreased triglyceride levels and prematurely activate autophagy, indicative of "starvation in the midst of plenty," a hallmark of Type I diabetes. Furthermore, circulating sugar levels are elevated in Df [dilp1-5] homozygotes during eating and fasting. In contrast, Df[dilp6] or Df[dilp7] animals showed no major metabolic defects. We discuss physiological differences between mammals and insects that may explain the unexpected survival of lean, 'diabetic' flies. |
| 巻・号 | 106(46) |
| ページ | 19617-22 |
| 公開日 | 2009-11-17 |
| DOI | 10.1073/pnas.0905083106 |
| PII | 0905083106 |
| PMID | 19887630 |
| PMC | PMC2780814 |
| MeSH | Animals Autophagy* Diabetes Mellitus, Type 1 / genetics Diabetes Mellitus, Type 1 / metabolism Disease Models, Animal Drosophila Proteins / genetics* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development* Drosophila melanogaster / metabolism* Gene Deletion Glucose / metabolism Homozygote Insulin / genetics* Triglycerides / metabolism |
| IF | 9.412 |
| 引用数 | 96 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
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| 各媒体での言及数の合計 | 0 |
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