RRC ID 1169
Author Teixeira AB, Moretti ML, Trabasso P, von Nowakonski A, Aoki FH, Vigorito AC, Miyaji M, Nishimura K, Taguchi H, Schreiber AZ.
Title Evaluation of Fusarium solani hyphae and conidia susceptibility to amphotericin B and itraconazole: study of a clinical case.
Journal Mycopathologia
Abstract Fusarium species are hyaline moulds belonging to the hyalohyphomycosis group that are usually found in the soil and plants. This organism has emerged as a cause of disseminated invasive disease. The correlation between in vitro value and clinical efficacy is low and many patients remain unresponsive to treatment despite in vitro susceptibility. We determined growth control for Fusarium solani using the BioCell-Tracer system that measures the growth rate of a single fungal hypha, and the effect of different concentrations of amphotericin B and itraconazole. The MIC for these two drugs was also determined by a broth microdilution technique, using RPMI 1640. Different MICs for amphotericin B were obtained by the two different methods. This paper describes a case of infection due to Fusarium solani in an allogeneic bone marrow transplanted patient, the microbiological diagnostic, antifungal susceptibility tests for conidia and hypha and clinical correlation.
Volume 160(4)
Pages 291-6
Published 2005-11-1
DOI 10.1007/s11046-005-0106-2
PMID 16244897
MeSH Adult Amphotericin B / pharmacology* Amphotericin B / therapeutic use Antifungal Agents / pharmacology* Antifungal Agents / therapeutic use Bone Marrow Transplantation / adverse effects DNA, Fungal / chemistry DNA, Fungal / genetics Fatal Outcome Female Fusarium / drug effects* Fusarium / growth & development Fusarium / isolation & purification Humans Immunocompromised Host Mycoses / drug therapy Mycoses / microbiology* Pregnancy Pregnancy Complications, Infectious / microbiology Sepsis / drug therapy Sepsis / microbiology*
IF 2.452
Times Cited 6
Pathogenic microorganisms F. solani?