論文 - 詳細
| RRC ID | 11698 |
|---|---|
| 著者 | Gallio M, Ofstad TA, Macpherson LJ, Wang JW, Zuker CS. |
| タイトル | The coding of temperature in the Drosophila brain. |
| ジャーナル | Cell |
| Abstract |
Thermosensation is an indispensable sensory modality. Here, we study temperature coding in Drosophila, and show that temperature is represented by a spatial map of activity in the brain. First, we identify TRP channels that function in the fly antenna to mediate the detection of cold stimuli. Next, we identify the hot-sensing neurons and show that hot and cold antennal receptors project onto distinct, but adjacent glomeruli in the Proximal-Antennal-Protocerebrum (PAP) forming a thermotopic map in the brain. We use two-photon imaging to reveal the functional segregation of hot and cold responses in the PAP, and show that silencing the hot- or cold-sensing neurons produces animals with distinct and discrete deficits in their behavioral responses to thermal stimuli. Together, these results demonstrate that dedicated populations of cells orchestrate behavioral responses to different temperature stimuli, and reveal a labeled-line logic for the coding of temperature information in the brain. |
| 巻・号 | 144(4) |
| ページ | 614-24 |
| 公開日 | 2011-2-18 |
| DOI | 10.1016/j.cell.2011.01.028 |
| PII | S0092-8674(11)00067-5 |
| PMID | 21335241 |
| PMC | PMC3336488 |
| MeSH | Animals Brain / physiology Cold Temperature Drosophila / physiology* Drosophila Proteins / metabolism Hot Temperature Sensory Receptor Cells / physiology TRPP Cation Channels / metabolism Thermosensing |
| IF | 38.637 |
| 引用数 | 123 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | brv1 NP4486 (DGRC#104694) |