論文 - 詳細
| RRC ID | 11800 |
|---|---|
| 著者 | Zhou S, Cerny AM, Zacharia A, Fitzgerald KA, Kurt-Jones EA, Finberg RW. |
| タイトル | Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus. |
| ジャーナル | J Virol |
| Abstract |
Type I interferons (IFNs) play a critical role in the host defense against viruses. Lymphocytic choriomeningitis virus (LCMV) infection induces robust type I IFN production in its natural host, the mouse. However, the mechanisms underlying the induction of type I IFNs in response to LCMV infection have not yet been clearly defined. In the present study, we demonstrate that IRF7 is required for both the early phase (day 1 postinfection) and the late phase (day 2 postinfection) of the type I IFN response to LCMV, and melanoma differentiation-associated gene 5 (MDA5)/mitochondrial antiviral signaling protein (MAVS) signaling is crucial for the late phase of the type I IFN response to LCMV. We further demonstrate that LCMV genomic RNA itself (without other LCMV components) is able to induce type I IFN responses in various cell types by activation of the RNA helicases retinoic acid-inducible gene I (RIG-I) and MDA5. We also show that expression of the LCMV nucleoprotein (NP) inhibits the type I IFN response induced by LCMV RNA and other RIG-I/MDA5 ligands. These virus-host interactions may play important roles in the pathogeneses of LCMV and other human arenavirus diseases. |
| 巻・号 | 84(18) |
| ページ | 9452-62 |
| 公開日 | 2010-9-1 |
| DOI | 10.1128/JVI.00155-10 |
| PII | JVI.00155-10 |
| PMID | 20592086 |
| PMC | PMC2937596 |
| MeSH | Adaptor Proteins, Signal Transducing / metabolism Animals Cell Line DEAD Box Protein 58 DEAD-box RNA Helicases / metabolism Host-Pathogen Interactions* Humans Interferon Regulatory Factor-7 / metabolism Interferon Type I / antagonists & inhibitors* Interferon Type I / biosynthesis* Interferon-Induced Helicase, IFIH1 Lymphocytic choriomeningitis virus / immunology* Mice Mice, Knockout Nucleoproteins / immunology RNA, Viral / immunology RNA, Viral / metabolism Viral Proteins / immunology |
| IF | 4.501 |
| 引用数 | 90 |
| WOS 分野 | VIROLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00858 RBRC01420 |