| RRC ID |
11800
|
| 著者 |
Zhou S, Cerny AM, Zacharia A, Fitzgerald KA, Kurt-Jones EA, Finberg RW.
|
| タイトル |
Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus.
|
| ジャーナル |
J Virol
|
| Abstract |
Type I interferons (IFNs) play a critical role in the host defense against viruses. Lymphocytic choriomeningitis virus (LCMV) infection induces robust type I IFN production in its natural host, the mouse. However, the mechanisms underlying the induction of type I IFNs in response to LCMV infection have not yet been clearly defined. In the present study, we demonstrate that IRF7 is required for both the early phase (day 1 postinfection) and the late phase (day 2 postinfection) of the type I IFN response to LCMV, and melanoma differentiation-associated gene 5 (MDA5)/mitochondrial antiviral signaling protein (MAVS) signaling is crucial for the late phase of the type I IFN response to LCMV. We further demonstrate that LCMV genomic RNA itself (without other LCMV components) is able to induce type I IFN responses in various cell types by activation of the RNA helicases retinoic acid-inducible gene I (RIG-I) and MDA5. We also show that expression of the LCMV nucleoprotein (NP) inhibits the type I IFN response induced by LCMV RNA and other RIG-I/MDA5 ligands. These virus-host interactions may play important roles in the pathogeneses of LCMV and other human arenavirus diseases.
|
| 巻・号 |
84(18)
|
| ページ |
9452-62
|
| 公開日 |
2010-9-1
|
| DOI |
10.1128/JVI.00155-10
|
| PII |
JVI.00155-10
|
| PMID |
20592086
|
| PMC |
PMC2937596
|
| MeSH |
Adaptor Proteins, Signal Transducing / metabolism
Animals
Cell Line
DEAD Box Protein 58
DEAD-box RNA Helicases / metabolism
Host-Pathogen Interactions*
Humans
Interferon Regulatory Factor-7 / metabolism
Interferon Type I / antagonists & inhibitors*
Interferon Type I / biosynthesis*
Interferon-Induced Helicase, IFIH1
Lymphocytic choriomeningitis virus / immunology*
Mice
Mice, Knockout
Nucleoproteins / immunology
RNA, Viral / immunology
RNA, Viral / metabolism
Viral Proteins / immunology
|
| IF |
4.501
|
| 引用数 |
90
|
|
WOS 分野
|
VIROLOGY
|
| リソース情報 |
| 実験動物マウス |
RBRC00858
RBRC01420 |
