RRC ID 1193
Author Akazawa A, Nishikawa K, Suzuki K, Asano R, Kumadaki I, Satoh H, Hagiwara K, Shin SJ, Yano T.
Title Induction of apoptosis in a human breast cancer cell overexpressing ErbB-2 receptor by alpha-tocopheryloxybutyric acid.
Journal Jpn. J. Pharmacol.
Abstract The overexpression of ErbB-2 receptor relates to malignant transformation of breast cancer. The present study was carried out to establish the usefulness of alpha-tocopheryloxybutyric acid (TE) as a chemotherapeutic agent for human breast cancer. TE caused induction of apoptosis in MDA-MB-453 cells overexpressing the ErbB-2 receptor. TE reduced levels of activated ErbB-2 receptor and Akt. In contrast, TE induced the activation of p38, and SB203580, a specific inhibitor for p38, attenuated the TE-induced apoptosis. These data indicate that simultaneous occurrences of Akt inhibition and p38 activation by TE result in the cell death.
Volume 89(4)
Pages 417-21
Published 2002-8
DOI 10.1254/jjp.89.417
PMID 12233821
MeSH Apoptosis / drug effects* Apoptosis / physiology Breast Neoplasms / genetics Breast Neoplasms / metabolism* Cell Survival / drug effects Cell Survival / physiology DNA Fragmentation / drug effects DNA Fragmentation / physiology Female Gene Expression Regulation, Neoplastic / drug effects Gene Expression Regulation, Neoplastic / physiology Humans Receptor, ErbB-2 / biosynthesis* Receptor, ErbB-2 / genetics Tumor Cells, Cultured Vitamin E / analogs & derivatives* Vitamin E / pharmacology*
Times Cited 25
WOS Category PHARMACOLOGY & PHARMACY
Resource
Human and Animal Cells MDA-MB-453