論文 - 詳細
| RRC ID | 1193 |
|---|---|
| 著者 | Akazawa A, Nishikawa K, Suzuki K, Asano R, Kumadaki I, Satoh H, Hagiwara K, Shin SJ, Yano T. |
| タイトル | Induction of apoptosis in a human breast cancer cell overexpressing ErbB-2 receptor by alpha-tocopheryloxybutyric acid. |
| ジャーナル | Jpn J Pharmacol |
| Abstract |
The overexpression of ErbB-2 receptor relates to malignant transformation of breast cancer. The present study was carried out to establish the usefulness of alpha-tocopheryloxybutyric acid (TE) as a chemotherapeutic agent for human breast cancer. TE caused induction of apoptosis in MDA-MB-453 cells overexpressing the ErbB-2 receptor. TE reduced levels of activated ErbB-2 receptor and Akt. In contrast, TE induced the activation of p38, and SB203580, a specific inhibitor for p38, attenuated the TE-induced apoptosis. These data indicate that simultaneous occurrences of Akt inhibition and p38 activation by TE result in the cell death. |
| 巻・号 | 89(4) |
| ページ | 417-21 |
| 公開日 | 2002-8-1 |
| DOI | 10.1254/jjp.89.417 |
| PMID | 12233821 |
| MeSH | Apoptosis / drug effects* Apoptosis / physiology Breast Neoplasms / genetics Breast Neoplasms / metabolism* Cell Survival / drug effects Cell Survival / physiology DNA Fragmentation / drug effects DNA Fragmentation / physiology Female Gene Expression Regulation, Neoplastic / drug effects Gene Expression Regulation, Neoplastic / physiology Humans Receptor, ErbB-2 / biosynthesis* Receptor, ErbB-2 / genetics Tumor Cells, Cultured Vitamin E / analogs & derivatives* Vitamin E / pharmacology* |
| 引用数 | 25 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| リソース情報 | |
| ヒト・動物細胞 | MDA-MB-453(RCB1192) |