Reference - Detail
| RRC ID | 11965 |
|---|---|
| Author | Kuzuhara T, Iwai Y, Takahashi H, Hatakeyama D, Echigo N. |
| Title | Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase. |
| Journal | PLoS Curr |
| Abstract |
The influenza A RNA polymerase possesses endonuclease activity to digest the host mRNA. Thus this endonuclease domain can be a target of anti-influenza A virus drug. Here we report that green tea catechins inhibit this viral endonuclease activity and that their galloyl group is important for their function. Docking simulations revealed that catechins with galloyl group fit well into the active pocket of the endonuclease domain to enable stable binding. Our results provide useful data that make it possible to refine and optimize catechin-based drug design more readily for stability. |
| Volume | 1 |
| Pages | RRN1052 |
| Published | 2009-10-13 |
| DOI | 10.1371/currents.rrn1052 |
| PII | k/-/-/1yn7909cwne80/2 |
| PMID | 20025206 |
| PMC | PMC2762814 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 22 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | pBMSA-PA (RDB01971) |