論文 - 詳細
| RRC ID | 12152 |
|---|---|
| 著者 | Takayama H, Takagi H, Larochelle WJ, Kapur RP, Merlino G. |
| タイトル | Ulcerative proctitis, rectal prolapse, and intestinal pseudo-obstruction in transgenic mice overexpressing hepatocyte growth factor/scatter factor. |
| ジャーナル | Lab Invest |
| Abstract |
Hepatocyte growth factor/scatter factor (HGF/SF) can stimulate growth of gastrointestinal epithelial cells in vitro; however, the physiological role of HGF/SF in the digestive tract is poorly understood. To elucidate this in vivo function, mice were analyzed in which an HGF/SF transgene was overexpressed throughout the digestive tract. Nearly a third of all HGF/SF transgenic mice in this study (28 of 87) died by 6 months of age as a result of sporadic intestinal obstruction of unknown etiology. Enteric ganglia were not overtly affected, indicating that the pathogenesis of this intestinal lesion was different from that operating in Hirschsprung's disease. Transgenic mice also exhibited a rectal inflammatory bowel disease (IBD) with a high incidence of anorectal prolapse. Expression of interleukin-2 was decreased in the transgenic colon, indicating that HGF/SF may influence regulation of the local intestinal immune system within the colon. These results suggest that HGF/SF plays an important role in the development of gastrointestinal paresis and chronic intestinal inflammation. HGF/SF transgenic mice may represent a useful model for the study of molecular mechanisms associated with a subset of IBD and intestinal pseudo-obstruction. Moreover, our data identify previously unappreciated side effects that may be encountered when using HGF/SF as a therapeutic agent. |
| 巻・号 | 81(3) |
| ページ | 297-305 |
| 公開日 | 2001-3-1 |
| DOI | 10.1038/labinvest.3780238 |
| PMID | 11310823 |
| MeSH | Animals Colitis, Ulcerative / mortality Colitis, Ulcerative / pathology* Female Gene Expression Hepatocyte Growth Factor / genetics* Humans Interleukin-2 / genetics Intestinal Pseudo-Obstruction / mortality Intestinal Pseudo-Obstruction / pathology* Intestine, Large / pathology Intestine, Large / physiology Male Mice Mice, Transgenic Proto-Oncogene Proteins c-kit / genetics Rectal Prolapse / mortality Rectal Prolapse / pathology* Survival Rate |
| IF | 4.197 |
| 引用数 | 13 |
| WOS 分野 | MEDICINE, RESEARCH & EXPERIMENTAL PATHOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 遺伝子材料 | pUC kit EH1 Mouse c-kit cDNA (RDB01344) |