RRC ID 12198
Author Kanamori Y, Kigawa J, Minagawa Y, Irie T, Oishi T, Shimada M, Takahashi M, Nakamura T, Sato K, Terakawa N.
Title A newly developed adenovirus-mediated transfer of a wild-type p53 gene increases sensitivity to cis-diamminedichloroplatinum (II) in p53-deleted ovarian cancer cells.
Journal Eur J Cancer
Abstract A new recombinant adenovirus carrying a wild-type p53 gene (AxCAp53) was developed and the combination effect of p53 gene transfer and cis-diamminedichloroplatinum (II) (CDDP) was examined in an ovarian cancer cell line, SK-OV-3, with deletion of the p53 gene. AxCAp53 showed a high efficiency of gene transduction and increased sensitivity to CDDP in the SK-OV-3 cells. It was found that the sensitivity of the cells to CDDP correlated with the amount of infectious units of virus per cell of AxCAp53 which correlated with p53 protein expression. The results suggest that the combination of CDDP and AxCAp53 may be a potential strategy for the therapy of CDDP-resistant ovarian cancer.
Volume 34(11)
Pages 1802-6
Published 1998-10-1
DOI 10.1016/s0959-8049(98)00199-3
PII S0959804998001993
PMID 9893672
MeSH Adenocarcinoma / pathology Adenocarcinoma / therapy* Adenoviruses, Human* Antineoplastic Agents / therapeutic use* Apoptosis Cisplatin / therapeutic use* Combined Modality Therapy Female Gene Transfer Techniques* Genes, p53* Humans Male Ovarian Neoplasms / pathology Ovarian Neoplasms / therapy* Tumor Cells, Cultured
IF 7.275
Times Cited 28
DNA material AxCALacZ Adex1CAlacZ (RDB02726)