論文 - 詳細
| RRC ID | 1225 |
|---|---|
| 著者 | Oka T, Ouchida M, Koyama M, Ogama Y, Takada S, Nakatani Y, Tanaka T, Yoshino T, Hayashi K, Ohara N, Kondo E, Takahashi K, Tsuchiyama J, Tanimoto M, Shimizu K, Akagi T. |
| タイトル | Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. |
| ジャーナル | Cancer Res |
| Abstract |
High-frequent silencing of hematopoietic cell-specific protein-tyrosine phosphatase SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas, as well as in many hematopoietic cell lines, which is supported by our previous observation of strong decrease of SHP1 mRNA and protein. The promoter methylation of the SHP1 gene was clearly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers near the SHP1 gene was shown in 79% of informative acute lymphoblastic leukemia cases. These results suggest that functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas. |
| 巻・号 | 62(22) |
| ページ | 6390-4 |
| 公開日 | 2002-11-15 |
| PMID | 12438221 |
| MeSH | Acute Disease Base Sequence DNA Methylation* Gene Expression Regulation, Leukemic Gene Silencing* Humans Intracellular Signaling Peptides and Proteins Leukemia / enzymology Leukemia / genetics* Leukemia, Myelogenous, Chronic, BCR-ABL Positive / enzymology Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics Leukemia, Myeloid / enzymology Leukemia, Myeloid / genetics Loss of Heterozygosity Lymphoma, T-Cell / enzymology Lymphoma, T-Cell / genetics* Molecular Sequence Data Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics Protein Tyrosine Phosphatase, Non-Receptor Type 6 Protein Tyrosine Phosphatases / biosynthesis Protein Tyrosine Phosphatases / genetics* RNA, Messenger / biosynthesis RNA, Messenger / genetics Tumor Cells, Cultured |
| IF | 9.727 |
| 引用数 | 164 |
| WOS 分野 | ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | ILT-Mat(RCB0475) |