RRC ID 12366
Author Takahashi KH, Okada Y, Teramura K.
Title Genome-wide deficiency mapping of the regions responsible for temporal canalization of the developmental processes of Drosophila melanogaster.
Journal J. Hered.
Abstract Developmental processes of organisms are programmed to proceed in a finely regulated manner and finish within a certain period of time depending on the ambient environmental conditions. Therefore, variation in the developmental period under controlled genetic and environmental conditions indicates innate instability of the developmental process. In this study, we aimed to determine whether a molecular machinery exists that regulates the canalization of the developmental period and, if so, to test whether the same mechanism also stabilizes a morphological trait. To search for regions that influence the instability of the developmental period, we conducted genome-wide deficiency mapping with 441 isogenic deficiency strains covering 65.5% of the Drosophila melanogaster genome. We found that 11 independent deficiencies significantly increased the instability of the developmental period and 5 of these also significantly increased the fluctuating asymmetry of wing shape although there was no significant correlation between the instabilities of developmental period and wing shape in general. These results suggest that canalization processes of the developmental period and morphological traits are at least partially independent. Our findings emphasize the potential importance of temporal variation in development as an indicator of developmental stability and canalization and provide a novel perspective for understanding the regulation of phenotypic variability.
Volume 102(4)
Pages 448-57
Published 2011-7
DOI 10.1093/jhered/esr026
PII esr026
PMID 21525178
MeSH Analysis of Variance Animals Base Sequence Crosses, Genetic Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development* Female Genetic Fitness / genetics Genetic Variation* Genome, Insect / genetics* Male Morphogenesis / genetics* Phenotype* Principal Component Analysis Sequence Deletion / genetics* Statistics, Nonparametric Wings, Animal / anatomy & histology Wings, Animal / growth & development
IF 2.574
Times Cited 14
WOS Category GENETICS & HEREDITY EVOLUTIONARY BIOLOGY
Resource
Drosophila Stocks of DGRC