| RRC ID |
1238
|
| Author |
Fujimoto H, Gabazza EC, Hataji O, Yuda H, D'Alessandro-Gabazza CN, Nakano M, Franco OE, Hayashi T, Suzuki K, Adachi Y, Taguchi O.
|
| Title |
Thrombin-activatable fibrinolysis inhibitor and protein C inhibitor in interstitial lung disease.
|
| Journal |
Am J Respir Crit Care Med
|
| Abstract |
Intraalveolar activation of the coagulation system due to reduced fibrinolytic function plays a critical role in the pathogenesis of interstitial lung disease. Recently, a new potent inhibitor of fibrinolysis, thrombin-activatable fibrinolysis inhibitor, has been isolated and characterized from human plasma. This study evaluated the levels of thrombin-activatable fibrinolysis inhibitor and protein C inhibitor, another suppressor of fibrinolysis, in the bronchoalveolar lavage fluid from patients with interstitial lung disease. There were 82 patients with interstitial lung disease and 8 normal subjects. The bronchoalveolar lavage fluid levels of thrombin-activatable fibrinolysis inhibitor and protein C inhibitor were significantly higher in all patients with interstitial lung disease than in normal subjects. Both inhibitors of fibrinolysis were significantly and inversely correlated with fibrinolytic activity in all patients. The levels of thrombin-activatable fibrinolysis inhibitor were significantly correlated with those of protein C inhibitor, thrombin-antithrombin complex, and monocyte chemoattractant protein-1. Reverse transcriptase-polymerase chain reaction showed that alveolar macrophages isolated from patients with interstitial lung disease as well as immortalized lung epithelial cell lines express thrombin-activatable fibrinolysis inhibitor antigen. Overall, these findings suggest that thrombin-activatable fibrinolysis inhibitor and protein C inhibitor may play important roles in the mechanism of intraalveolar hypofibrinolysis associated with interstitial lung diseases.
|
| Volume |
167(12)
|
| Pages |
1687-94
|
| Published |
2003-6-15
|
| DOI |
10.1164/rccm.200208-905OC
|
| PII |
200208-905OC
|
| PMID |
12615624
|
| MeSH |
Alveolitis, Extrinsic Allergic / pathology
Antithrombin III / analysis
Biopsy
Blood Coagulation Disorders / etiology
Blood Coagulation Disorders / pathology
Bronchoalveolar Lavage Fluid / chemistry*
Carboxypeptidase B2 / analysis*
Carboxypeptidase B2 / immunology
Case-Control Studies
Cell Line
Chemokine CCL2 / analysis
Collagen Diseases / pathology
Female
Humans
Lung Diseases, Interstitial / complications
Lung Diseases, Interstitial / metabolism
Lung Diseases, Interstitial / pathology*
Macrophages, Alveolar / chemistry
Macrophages, Alveolar / cytology
Macrophages, Alveolar / immunology
Male
Peptide Hydrolases / analysis
Plasminogen / analysis
Protein C Inhibitor / analysis*
Pulmonary Eosinophilia / pathology
Reverse Transcriptase Polymerase Chain Reaction
Sarcoidosis, Pulmonary / pathology
|
| IF |
17.452
|
| Times Cited |
33
|
|
WOS Category
|
RESPIRATORY SYSTEM
CRITICAL CARE MEDICINE
|
| Resource |
| Human and Animal Cells |
Hep G2 |
