Reference - Detail
| RRC ID | 12442 |
|---|---|
| Author | Kim YH, Choi EM. |
| Title | Stimulation of osteoblastic differentiation and inhibition of interleukin-6 and nitric oxide in MC3T3-E1 cells by pomegranate ethanol extract. |
| Journal | Phytother Res |
| Abstract |
In this experiment, we studied the effects of pomegranate fruit extract (PE) on the function of osteoblastic MC3T3-E1 cells and the production of local factors in osteoblasts. PE (16 approximately 250 microg/ml) significantly increased the growth of MC3T3-E1 cells (P < 0.05). Moreover, PE (50 microg/ml) caused a significant elevation of alkaline phosphatase (ALP) activity and collagen content in the cells. We then examined the effect of PE on the TNF-alpha-induced production of interleukin-6 (IL-6) and nitric oxide (NO) in osteoblasts. Treatment with PE (10 approximately 50 microg/ml) decreased the TNF-alpha (10(-10) M)-induced production of IL-6 and NO in osteoblasts. |
| Volume | 23(5) |
| Pages | 737-9 |
| Published | 2009-5-1 |
| DOI | 10.1002/ptr.2587 |
| PMID | 19107859 |
| MeSH | Alkaline Phosphatase / metabolism Animals Cell Differentiation / drug effects* Cell Line Collagen / metabolism Interleukin-6 / metabolism* Lythraceae / chemistry Mice Nitric Oxide / metabolism* Osteoblasts / drug effects* Plant Extracts / pharmacology* Tumor Necrosis Factor-alpha / metabolism |
| IF | 4.087 |
| Times Cited | 12 |
| WOS Category | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| Resource | |
| Human and Animal Cells | MC3T3-E1(RCB1126) |