Reference - Detail
RRC ID | 1258 |
---|---|
Author | Iwata K, Ogata S, Okumura K, Taguchi H. |
Title | Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds. |
Journal | Biosci Biotechnol Biochem |
Abstract |
Water-soluble vitamin, niacin, and its related compounds were examined for their differentiation-inducing activity in human promyelocytic leukemia cells (HL-60). Among the compounds, which inhibited cell proliferation measured by MTT assay, isonicotinic acid, nicotinamide N-oxide, and nicotinamide induced NBT reducing activity. HL-60 cells were differentiated into granulocyte-like cells by these compounds, judging from morphological changes and loss of nonspecific esterase activity. The differentiation-inducing activity of water-soluble vitamin and its related compounds suggest that these compounds may be applicable for medical use. |
Volume | 67(5) |
Pages | 1132-5 |
Published | 2003-5-1 |
DOI | 10.1271/bbb.67.1132 |
PMID | 12834294 |
MeSH | Cell Differentiation / drug effects Cell Division / drug effects Cell Survival / drug effects HL-60 Cells Humans Isonicotinic Acids / pharmacology L-Lactate Dehydrogenase / metabolism Niacin / analogs & derivatives* Niacin / pharmacology* |
IF | 1.516 |
Times Cited | 21 |
WOS Category | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
Resource | |
Human and Animal Cells | HL60(RCB0041) |