| RRC ID |
12671
|
| 著者 |
Ohno Y, Sofue N, Imaoku T, Morishita E, Kumafuji K, Sasa M, Serikawa T.
|
| タイトル |
Serotonergic modulation of absence-like seizures in groggy rats: a novel rat model of absence epilepsy.
|
| ジャーナル |
J Pharmacol Sci
|
| Abstract |
To explore the role of the serotonergic system in modulating absence seizures, we examined the effects of 5-HT(1A) and 5-HT(2) agonists on the incidence of spike-and-wave discharges (SWD) in Groggy (GRY) rats, a novel rat model of absence-like epilepsy. GRY rats exhibited spontaneous absence-like seizures characterized by the incidence of sudden immobile posture and synchronously-associated SWD. The total duration of SWD in GRY rats was about 300 - 400 s/15-min observation period under the control conditions. However, the incidence of SWD was markedly reduced either by the 5-HT(1A) agonist (±)-8-hydroxy-2-(di-n-propylamino)-tetralin [(±)8-OH-DPAT] or the 5-HT(2) agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(±)DOI]. The 5-HT reuptake inhibitors, fluoxetine and clomipramine, also inhibited the SWD generation. In addition, the inhibitory effects of (±)8-OH-DPAT and (±)DOI were reversed by WAY-100135 (5-HT(1A) antagonist) and ritanserin (5-HT(2) antagonist), respectively. The present results suggest that the serotonergic system negatively regulates the incidence of absence seizures by stimulation of 5-HT(1A) and 5-HT(2) receptors.
|
| 巻・号 |
114(1)
|
| ページ |
99-105
|
| 公開日 |
2010-1-1
|
| DOI |
10.1254/jphs.10156fp
|
| PII |
JST.JSTAGE/jphs/10156FP
|
| PMID |
20736508
|
| MeSH |
Animals
Calcium Channels / genetics
Disease Models, Animal*
Epilepsy, Absence / diagnosis
Epilepsy, Absence / genetics*
Epilepsy, Absence / prevention & control*
Female
Humans
Male
Mutation, Missense
Rats
Rats, Mutant Strains
Receptor, Serotonin, 5-HT1A / physiology*
Receptors, Serotonin, 5-HT2 / physiology*
Serotonin / physiology*
Serotonin Receptor Agonists / pharmacology
Serotonin Receptor Agonists / therapeutic use
|
| IF |
2.835
|
| 引用数 |
18
|
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
|
| リソース情報 |
| ラット |
GRY/Idr(strainID=498) |
