RRC ID 132
Author Hubner N, Wallace CA, Zimdahl H, Petretto E, Schulz H, Maciver F, Mueller M, Hummel O, Monti J, Zidek V, Musilova A, Kren V, Causton H, Game L, Born G, Schmidt S, Müller A, Cook SA, Kurtz TW, Whittaker J, Pravenec M, Aitman TJ.
Title Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.
Journal Nat. Genet.
Abstract Integration of genome-wide expression profiling with linkage analysis is a new approach to identifying genes underlying complex traits. We applied this approach to the regulation of gene expression in the BXH/HXB panel of rat recombinant inbred strains, one of the largest available rodent recombinant inbred panels and a leading resource for genetic analysis of the highly prevalent metabolic syndrome. In two tissues important to the pathogenesis of the metabolic syndrome, we mapped cis- and trans-regulatory control elements for expression of thousands of genes across the genome. Many of the most highly linked expression quantitative trait loci are regulated in cis, are inherited essentially as monogenic traits and are good candidate genes for previously mapped physiological quantitative trait loci in the rat. By comparative mapping we generated a data set of 73 candidate genes for hypertension that merit testing in human populations. Mining of this publicly available data set is expected to lead to new insights into the genes and regulatory pathways underlying the extensive range of metabolic and cardiovascular disease phenotypes that segregate in these recombinant inbred strains.
Volume 37(3)
Pages 243-53
Published 2005-3
DOI 10.1038/ng1522
PII ng1522
PMID 15711544
MeSH Animals Blood Pressure / genetics Gene Expression Profiling* Genetic Linkage Quantitative Trait Loci Rats Recombination, Genetic Transcription, Genetic*
IF 27.125
Times Cited 362
WOS Category GENETICS & HEREDITY
Resource
Rats