| RRC ID |
144
|
| Author |
Nishihashi T, Trandafir CC, Wang A, Ji X, Kurahashi K.
|
| Title |
Enhanced reactivity to vasopressin in rat basilar arteries during vasospasm after subarachnoid hemorrhage.
|
| Journal |
Eur J Pharmacol
|
| Abstract |
Subarachnoid hemorrhage increases the plasma level of vasopressin, a well-known vasoconstrictor. We examined the sensitivity to vasopressin in rat basilar artery after subarachnoid hemorrhage using a rat subarachnoid hemorrhage model. Vasospasm was observed 1-2 days after subarachnoid hemorrhage induction, and the contractile response to vasopressin in rat basilar arteries was assessed. The concentration-response curve for vasopressin in subarachnoid hemorrhage (1 day) rats shifted leftward compared with that of control rats. The concentration-response curve for vasopressin V(1) receptor agonist also shifted leftward and upward compared with that of control rats. The concentration-response curve for vasopressin was inhibited not by vasopressin V(2) receptor antagonist but by vasopressin V(1) receptor antagonist. Thus, it was demonstrated that the vasoconstricting effect of vasopressin was significantly enhanced in the vasospasm phase after subarachnoid hemorrhage.
|
| Volume |
513(1-2)
|
| Pages |
93-100
|
| Published |
2005-4-18
|
| DOI |
10.1016/j.ejphar.2005.01.051
|
| PII |
S0014-2999(05)00055-5
|
| PMID |
15878713
|
| MeSH |
Animals
Antidiuretic Hormone Receptor Antagonists
Basilar Artery / drug effects*
Basilar Artery / pathology
Basilar Artery / physiopathology
Dose-Response Relationship, Drug
Endothelium, Vascular / physiology
In Vitro Techniques
Male
Morpholines / pharmacology
Oxytocin / analogs & derivatives*
Oxytocin / pharmacology
Potassium Chloride / pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Vasopressin / agonists
Spiro Compounds / pharmacology
Subarachnoid Hemorrhage / complications*
Time Factors
Vasoconstriction / drug effects*
Vasoconstrictor Agents / pharmacology*
Vasopressins / blood
Vasopressins / pharmacology*
Vasospasm, Intracranial / etiology
Vasospasm, Intracranial / physiopathology*
|
| IF |
3.263
|
| Times Cited |
17
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
|
| Resource |
| Rats |
|
