論文 - 詳細
| RRC ID | 1453 |
|---|---|
| 著者 | Shibata M, Kodani I, Osaki M, Araki K, Adachi H, Ryoke K, Ito H. |
| タイトル | Cyclo-oxygenase-1 and -2 expression in human oral mucosa, dysplasias and squamous cell carcinomas and their pathological significance. |
| ジャーナル | Oral Oncol |
| Abstract |
Cyclo-oxygenase (COX) is a key enzyme in the conversion of arachidonic acid to prostanoids. The expression of its isoforms, COX-1 and -2 is found in many human malignancies. This study analyzed the correlation between COX expression and the pathobiological nature of human oral mucosa, dysplasias and squamous cell carcinomas (SCCs). We examined 9 specimens of normal oral epithelia, 65 lesions with dysplasias and 50 SCCs. Labeling indices (LIs) for COX-1, COX-2, Ki-67 and P53, microvessel density (MVD) and apoptotic index (AI) were evaluated using immunohistochemistry and TUNEL methods. Western blot analysis of COX-1 and -2 was performed on four human oral SCC cell lines, all of which showed expression. The LIs for COX-1 and -2 were higher for the dysplasias than the SCCs. LIs of COX-2 but not COX-1 correlated with the histological grade of dysplasia, being highest for the severe dysplasias (p < 0.05). In contrast, the COX-2 LIs as well as COX-1 were significantly (p < 0.05) inversely correlated with the histological differentiation of the SCCs. COX-2 expression was significantly correlated with LIs of COX-1 for dysplasia (p < 0.05), but not for the SCCs. In addition no significant relationship was noted between COX-2 expression and the Lis of Ki-67, P53, AI as well as MVD for the dysplasias and SCCs. The expression of COX-1 and -2 is correlated with early stage tumorigenesis and cellular differentiation of SCCs in the oral dysplasia-carcinoma sequence. |
| 巻・号 | 41(3) |
| ページ | 304-12 |
| 公開日 | 2005-3-1 |
| DOI | 10.1016/j.oraloncology.2004.09.009 |
| PII | S1368-8375(04)00221-0 |
| PMID | 15743693 |
| MeSH | Apoptosis Biomarkers, Tumor / analysis* Blotting, Western / methods Carcinoma, Squamous Cell / blood supply Carcinoma, Squamous Cell / enzymology* Carcinoma, Squamous Cell / pathology Cyclooxygenase 1 Cyclooxygenase 2 Humans Immunohistochemistry / methods In Situ Nick-End Labeling Ki-67 Antigen / analysis Membrane Proteins Mouth Mucosa / enzymology* Mouth Mucosa / pathology Mouth Neoplasms / blood supply Mouth Neoplasms / enzymology* Mouth Neoplasms / pathology Neovascularization, Pathologic Precancerous Conditions / blood supply Precancerous Conditions / enzymology* Precancerous Conditions / pathology Prostaglandin-Endoperoxide Synthases / analysis* Statistics, Nonparametric Tumor Suppressor Protein p53 / analysis |
| IF | 3.979 |
| 引用数 | 81 |
| WOS 分野 | DENTISTRY, ORAL SURGERY & MEDICINE ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | SCCKN(RCB0441) SCCTF(RCB0442) |