| RRC ID |
1468
|
| 著者 |
Koyama Y, Suzuki T, Kajiya A, Isemura M.
|
| タイトル |
Stimulation of IL-8 production by Aralia cordate lectin in human colon carcinoma Caco-2 cells.
|
| ジャーナル |
Biosci Biotechnol Biochem
|
| Abstract |
Some lectins are known to stimulate interleukin-8 (IL-8) productions in human colon carcinoma Caco-2 cells. Since IL-8 may cause deleterious effects, we examined this stimulatory activity of Aralia cordate lectin (ACL) and Wasabia japonica lectin (WJL), both of which we isolated recently. The results indicate that ACL exhibited strong stimulatory activity for IL-8 protein production, while WJL showed marginal activity. The activity of ACL was associated with high enhancement of IL-8 gene expression. The effect of ACL was abolished almost completely in the presence of brefeldin A, indicating that internalization into cells is necessary for ACL to exert activity. The findings suggest that ingestion of a large amount of raw vegetable Aralia cordate might cause unfavorable effects on the colon.
|
| 巻・号 |
69(1)
|
| ページ |
202-5
|
| 公開日 |
2005-1-1
|
| DOI |
10.1271/bbb.69.202
|
| PII |
JST.JSTAGE/bbb/69.202
|
| PMID |
15665486
|
| MeSH |
Aralia / chemistry*
Brefeldin A / pharmacology
Caco-2 Cells
Colon / drug effects*
Dose-Response Relationship, Drug
Gene Expression / drug effects
Humans
Interleukin-8 / biosynthesis*
Plant Lectins / pharmacology*
RNA, Messenger
Wasabia / chemistry
|
| IF |
1.516
|
| 引用数 |
4
|
|
WOS 分野
|
CHEMISTRY, APPLIED
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
CACO-2(RCB0988) |
