Reference - Detail
| RRC ID | 1530 |
|---|---|
| Author | Kishimoto S, Muramatsu M, Gokoh M, Oka S, Waku K, Sugiura T. |
| Title | Endogenous cannabinoid receptor ligand induces the migration of human natural killer cells. |
| Journal | J Biochem |
| Abstract |
2-Arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors (CB1 and CB2). Evidence is gradually accumulating which shows that 2-arachidonoylglycerol plays important physiological roles in several mammalian tissues and cells, yet the details remain ambiguous. In this study, we first examined the effects of 2-arachidonoylglycerol on the motility of human natural killer cells. We found that 2-arachidonoylglycerol induces the migration of KHYG-1 cells (a natural killer leukemia cell line) and human peripheral blood natural killer cells. The migration of natural killer cells induced by 2-arachidonoylglycerol was abolished by treating the cells with SR144528, a CB2 receptor antagonist, suggesting that the CB2 receptor is involved in the 2-arachidonoylglycerol-induced migration. In contrast to 2-arachidonoylglycerol, anandamide, another endogenous cannabinoid receptor ligand, did not induce the migration. Delta9-tetrahydrocannabinol, a major psychoactive constituent of marijuana, also failed to induce the migration; instead, the addition of delta9-tetrahydrocannabinol together with 2-arachidonoylglycerol abolished the migration induced by 2-arachidonoylglycerol. It is conceivable that the endogenous ligand for the cannabinoid receptor, that is, 2-arachidonoylglycerol, affects natural killer cell functions such as migration, thereby contributing to the host-defense mechanism against infectious viruses and tumor cells. |
| Volume | 137(2) |
| Pages | 217-23 |
| Published | 2005-2-1 |
| DOI | 10.1093/jb/mvi021 |
| PII | 137/2/217 |
| PMID | 15749836 |
| MeSH | Arachidonic Acids / pharmacology Arachidonic Acids / physiology* Camphanes / pharmacology Cell Line Cell Movement / drug effects Cell Movement / physiology* Endocannabinoids Glycerides / pharmacology Glycerides / physiology* Humans Killer Cells, Natural / drug effects Killer Cells, Natural / immunology* Ligands Pyrazoles / pharmacology Receptor, Cannabinoid, CB2 / antagonists & inhibitors Receptor, Cannabinoid, CB2 / genetics Receptor, Cannabinoid, CB2 / physiology* |
| IF | 2.476 |
| Times Cited | 71 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Human and Animal Cells | Jurkat(RCB0806) |