| RRC ID |
15418
|
| Author |
Akiyama K, Maruyama M, Yamauchi S, Nakashima Y, Nakato T, Tago R, Sugahara T, Kishida T, Koba Y.
|
| Title |
Antimicrobiological activity of lignan: effect of benzylic oxygen and stereochemistry of 2,3-dibenzyl-4-butanolide and 3,4-dibenzyltetrahydrofuran lignans on activity.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
The effect of oxidation degree at the benzylic position of 2,3-dibenzyl-4-butanolide and 3,4-dibenzyltetrahydrofuran lignans on the antimicrobiological activity was examined. The highest oxidation degree at the benzylic position of 2,3-dibenzyl-4-butanolide gave the greatest activity, and 3,4-dibenzoyltetrahydrofuran showed the highest antifungal activity. The relationship between stereochemistry and activity was also examined. Both enantiomers of cis-matairesinol were synthesized for the first time, one of the cis-matairesinols showing antibacterial activity.
|
| Volume |
71(7)
|
| Pages |
1745-51
|
| Published |
2007-7-1
|
| DOI |
10.1271/bbb.70168
|
| PII |
JST.JSTAGE/bbb/70168
|
| PMID |
17617715
|
| MeSH |
4-Butyrolactone / chemistry
4-Butyrolactone / pharmacology
Anti-Infective Agents / chemistry
Anti-Infective Agents / pharmacology*
Bacillus subtilis / drug effects
Furans / chemistry
Furans / pharmacology*
Lignans / chemistry
Lignans / pharmacology*
Molecular Conformation
Oxygen / chemistry*
Pseudomonas fluorescens / drug effects
Staphylococcus aureus / drug effects
Structure-Activity Relationship
|
| IF |
1.516
|
| Times Cited |
24
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| General Microbes |
JCM 1649
JCM 6977
JCN 7579
JCM 11481 |
