論文 - 詳細
| RRC ID | 15424 |
|---|---|
| 著者 | Morimura K, Yamazaki C, Hattori Y, Makabe H, Kamo T, Hirota M. |
| タイトル | A tyrosinase inhibitor, Daedalin A, from mycelial culture of Daedalea dickinsii. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
A chromene-type compound, daedalin A (1), was isolated from mycelial culture broth of Daedalea dickinsii. Based on spectroscopic data, the structure of 1 was found to be (2R)-6-hydroxy-2-hydroxymethyl-2-methyl-2H-chromene. Daedalin A (1) strongly inhibited the activity of tyrosinase (IC(50): 194 muM). In addition, 1 also showed 1,1-diphenyl-2-picrylhydrazyl scavenging activity (IC(50): 16.9 microM) and superoxide anion scavenging activity (IC(50): 28.5 microM). |
| 巻・号 | 71(11) |
| ページ | 2837-40 |
| 公開日 | 2007-11-1 |
| DOI | 10.1271/bbb.70266 |
| PII | JST.JSTAGE/bbb/70266 |
| PMID | 17986791 |
| MeSH | Benzopyrans / chemistry* Benzopyrans / isolation & purification Benzopyrans / pharmacology* Biphenyl Compounds Free Radical Scavengers / chemistry* Free Radical Scavengers / isolation & purification Free Radical Scavengers / pharmacology* Monophenol Monooxygenase / antagonists & inhibitors Mycelium / chemistry Peptides / chemistry* Peptides / isolation & purification Peptides / pharmacology* Picrates / chemistry Polyporales / chemistry* Superoxides / chemistry |
| IF | 1.516 |
| 引用数 | 13 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| 一般微生物 | JCM 12697 |