| RRC ID |
15426
|
| Author |
Maruyama M, Yamauchi S, Akiyama K, Sugahara T, Kishida T, Koba Y.
|
| Title |
Antibacterial activity of a virgatusin-related compound.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
The relationship between antibacterial activity of tetra-substituted tetrahydrofuran lignans (1-4) and their absolute configurations was tested. Only compound 4 among two virgatusins and two related compounds exhibited growth inhibitory activity against the Gram-positive bacteria Bacillus subtilis, Staphylococcus aureus and Listeria denitrificans. Compound 4 affected the growth of B. subtilis in a bactericidic manner, and its ability to dissipate the cytoplasmic membrane potential was investigated using the fluorescence probe 3,3'-dipropylthiadicarbocyanine iodide. These results suggested that compound 4 damages cells by causing the loss of the proton motive force and disruption of the cellular integrity of the membrane, leading to cell death. In addition, it was shown that the antibacterial activity of a lignan was closely related to its absolute configuration and functional groups.
|
| Volume |
71(3)
|
| Pages |
677-80
|
| Published |
2007-3-1
|
| DOI |
10.1271/bbb.60429
|
| PII |
JST.JSTAGE/bbb/60429
|
| PMID |
17341839
|
| MeSH |
Anti-Bacterial Agents / pharmacology*
Benzothiazoles / chemistry
Carbocyanines / chemistry
Cell Membrane / drug effects*
Fluorescent Dyes / chemistry*
Furans / pharmacology*
Gram-Positive Bacteria / drug effects
Gram-Positive Bacteria / growth & development*
Membrane Potentials / drug effects*
Microbial Viability / drug effects
|
| IF |
1.516
|
| Times Cited |
22
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| General Microbes |
JCM 1649
JCM 6977
JCN 7579
JCM 11481 |
