| RRC ID |
15612
|
| Author |
Tago R, Yamauchi S, Maruyama M, Akiyama K, Sugahara T, Kishida T, Koba Y.
|
| Title |
Structure-antibacterial activity relationship for 9-O,9'-O-demethyl (+)-virgatusin.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
The relationship between the antibacterial activity and structure of 9-O,9'-O-demethyl (+)-virgatusin (Virg 3) was examined. The conversion of hydroxy groups on the 9 and 9' positions to amino groups increased the activity. It was found that the 3'-methoxy group was more important for higher activity than the 4'-methoxy group on the 7'-phenyl group, and that the 3,4-methylenedioxy group on the 7-phenyl group was necessary for activity.
|
| Volume |
72(4)
|
| Pages |
1032-7
|
| Published |
2008-4-1
|
| DOI |
10.1271/bbb.70783
|
| PII |
JST.JSTAGE/bbb/70783
|
| PMID |
18391445
|
| MeSH |
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology*
Biological Products / chemistry
Biological Products / pharmacology
Furans / chemistry*
Furans / pharmacology*
Lignans / chemistry
Lignans / pharmacology
Microbial Sensitivity Tests
Structure-Activity Relationship
|
| IF |
1.516
|
| Times Cited |
6
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| General Microbes |
JCM 1649
JCM 6977
JCM 11481 |
