論文 - 詳細
| RRC ID | 15719 |
|---|---|
| 著者 | Nakato T, Yamauchi S, Tago R, Akiyama K, Maruyama M, Sugahara T, Kishida T, Koba Y. |
| タイトル | Syntheses and antimicrobial activity of tetrasubstituted tetrahydrofuran lignan stereoisomers. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
The syntheses of all stereoisomers of tetrasubstituted tetrahydrofuran lignan were accomplished, and the antimicrobial activity was examined. The 9,9'-diol compound bearing (7R,7'R,8R,8'R) and (7R,7'S,8R,8'R) stereochemistry showed the strongest antibacterial activity against Listeria denitrificans and Bacillus subtilis, respectively. It was also found that (-)-virgatusin bearing (7S,7'R,8S,8'S) stereochemistry had strongest antifungal activity. |
| 巻・号 | 73(7) |
| ページ | 1608-17 |
| 公開日 | 2009-7-1 |
| DOI | 10.1271/bbb.90107 |
| PII | JST.JSTAGE/bbb/90107 |
| PMID | 19584535 |
| MeSH | Anti-Infective Agents / chemical synthesis Anti-Infective Agents / chemistry* Anti-Infective Agents / pharmacology* Bacteria / drug effects Furans / chemistry* Lignans / chemical synthesis Lignans / chemistry* Lignans / pharmacology* Microbial Sensitivity Tests Stereoisomerism Structure-Activity Relationship |
| IF | 1.516 |
| 引用数 | 10 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| 一般微生物 | JCM 1649 JCM 6977 JCM 7579 JCM 11481 |