| RRC ID |
15805
|
| Author |
Yoneyama F, Ohno K, Imura Y, Li M, Zendo T, Nakayama J, Matsuzaki K, Sonomoto K.
|
| Title |
Lacticin Q-mediated selective toxicity depending on physicochemical features of membrane components.
|
| Journal |
Antimicrob Agents Chemother
|
| Abstract |
Lacticin Q, a lactococcal pore-forming bacteriocin, shows activity toward Gram-positive bacteria but not Gram-negative bacteria. Lacticin Q did not induce permeability of the outer membrane of Gram-negative bacteria. Experiments using model membranes containing outer membrane components suggested that lacticin Q binds to the outer membrane of Gram-negative bacteria but is unable to penetrate it. The lack of activity of lacticin Q was attributed to physicochemical features of the outer membrane components.
|
| Volume |
55(5)
|
| Pages |
2446-50
|
| Published |
2011-5-1
|
| DOI |
10.1128/AAC.00808-10
|
| PII |
AAC.00808-10
|
| PMID |
21282423
|
| PMC |
PMC3088220
|
| MeSH |
Bacteriocins / pharmacology*
Cell Membrane / drug effects*
Cell Membrane / metabolism*
Gram-Negative Bacteria / drug effects
Gram-Negative Bacteria / metabolism
Gram-Positive Bacteria / drug effects
Gram-Positive Bacteria / metabolism
Microbial Sensitivity Tests
Models, Biological
|
| IF |
4.904
|
| Times Cited |
16
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
MICROBIOLOGY
|
| Resource |
| General Microbes |
JCM 2257
JCM 5890 |
