Reference - Detail
| RRC ID | 15826 |
|---|---|
| Author | Hino S, Ito H, Bito H, Kawagishi H, Morita T. |
| Title | Ameliorating effects of short-chain inulin-like fructans on the healing stage of trinitrobenzene sulfonic acid-induced colitis in rats. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
We evaluated the ameliorating effects of short-chain inulin-like fructans (SIF) with different degrees of polymerization (DP) on the healing stage of trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. The rats were assigned to 3 groups 10 d after the colitis induction, and fed for 24 d on a control diet or diet including 60 g of DP4 or DP8/kg. The fecal myeloperoxidase (MPO) activity and IgA concentration were monitored every 7 d. The colonic MPO activities and cecal concentrations of organic acids, lactobacilli, bifidobacteria, mucin and IgA were measured at the end of the study. DP4, but not DP8, significantly reduced the colonic inflammation accompanied by higher cecal concentrations of short-chain fatty acids, propionate in particular, and lactic acid-producing bacteria. DP4 therefore accelerated the healing process of TNBS-induced colitis, even when the treatment was initiated after inducing colitis. |
| Volume | 75(11) |
| Pages | 2169-74 |
| Published | 2011-1-1 |
| DOI | 10.1271/bbb.110460 |
| PII | JST.JSTAGE/bbb/110460 |
| PMID | 22056441 |
| MeSH | Animals Bacteria / drug effects Colitis / chemically induced Colitis / diet therapy* Diet* Fructans / administration & dosage* Fructans / chemistry Immunoglobulin A / analysis Inulin / chemical synthesis Inulin / pharmacology* Male Peroxidase / analysis Polymerization Rats Rats, Sprague-Dawley Rats, Wistar Trinitrobenzenesulfonic Acid / pharmacology |
| IF | 1.516 |
| Times Cited | 4 |
| WOS Category | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| General Microbes | JCM 1190 JCM 1717 |