論文 - 詳細
| RRC ID | 15944 |
|---|---|
| 著者 | Aoki Y, Matsumoto D, Kawaide H, Natsume M. |
| タイトル | Physiological role of germicidins in spore germination and hyphal elongation in Streptomyces coelicolor A3(2). |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
Four germicidin homologs were isolated from a liquid culture of Streptomyces coelicolor A3(2). These were identified as germicidins A, B and C, and surugapyrone A (germicidin D). Absolute stereochemistry of the chiral center in germicidins A and C is determined to be S. All germicidins inhibited germination of S. coelicolor A3(2) spores above 1 μg ml(-1). S. coelicolor A3(2) spores collected from a single petri dish (9 cm i.d.) contained 5.4 μg of germicidin A (-2.7 × 10(-14) g per spore), which accounts for 2.3% of the spore extract, and contents of germicidins B, C and D were 0.2-0.8 μg. The activity of the spore extract corresponded well with the sum of the activity of each germicidin, which was estimated from the content and dose-response curve, which indicates that germicidins functions as self-germination inhibitors in S. coelicolor A3(2). Inhibitory action of germicidin A on spore germination was reversible and germicidin A inhibited not only spore germination but also hyphal elongation. |
| 巻・号 | 64(9) |
| ページ | 607-11 |
| 公開日 | 2011-9-1 |
| DOI | 10.1038/ja.2011.59 |
| PII | ja201159 |
| PMID | 21792209 |
| MeSH | Pyrones / chemistry Pyrones / isolation & purification Pyrones / metabolism* Spores, Bacterial / growth & development* Streptomyces coelicolor / metabolism* |
| IF | 2.668 |
| 引用数 | 33 |
| WOS 分野 | PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 4265 |