論文 - 詳細
| RRC ID | 16034 |
|---|---|
| 著者 | Ohta M, Sato M, Yamamoto M. |
| タイトル | Spindle pole body components are reorganized during fission yeast meiosis. |
| ジャーナル | Mol Biol Cell |
| Abstract |
During meiosis, the centrosome/spindle pole body (SPB) must be regulated in a manner distinct from that of mitosis to achieve a specialized cell division that will produce gametes. In this paper, we demonstrate that several SPB components are localized to SPBs in a meiosis-specific manner in the fission yeast Schizosaccharomyces pombe. SPB components, such as Cut12, Pcp1, and Spo15, which stay on the SPB during the mitotic cell cycle, disassociate from the SPB during meiotic prophase and then return to the SPB immediately before the onset of meiosis I. Interestingly, the polo kinase Plo1, which normally localizes to the SPB during mitosis, is excluded from them in meiotic prophase, when meiosis-specific, horse-tail nuclear movement occurs. We found that exclusion of Plo1 during this period was essential to properly remodel SPBs, because artificial targeting of Plo1 to SPBs resulted in an overduplication of SPBs. We also found that the centrin Cdc31 was required for meiotic SPB remodeling. Thus Plo1 and a centrin play central roles in the meiotic SPB remodeling, which is essential for generating the proper number of meiotic SPBs and, thereby provide unique characteristics to meiotic divisions. |
| 巻・号 | 23(10) |
| ページ | 1799-811 |
| 公開日 | 2012-5-1 |
| DOI | 10.1091/mbc.E11-11-0951 |
| PII | mbc.E11-11-0951 |
| PMID | 22438582 |
| PMC | PMC3350546 |
| MeSH | CDC2 Protein Kinase / metabolism Calcium-Binding Proteins / metabolism Cell Cycle Proteins / metabolism Centrosome / metabolism* Chromosome Segregation Green Fluorescent Proteins / metabolism Kinetochores / metabolism MAP Kinase Signaling System Meiotic Prophase I* Microtubule-Associated Proteins / metabolism Mitogen-Activated Protein Kinases / metabolism Nuclear Proteins / metabolism Phosphoproteins / metabolism Protein Serine-Threonine Kinases / metabolism* Protein Transport Recombinant Fusion Proteins / metabolism Schizosaccharomyces / cytology Schizosaccharomyces / metabolism* Schizosaccharomyces / physiology Schizosaccharomyces pombe Proteins / metabolism* Spindle Apparatus / metabolism |
| IF | 3.791 |
| 引用数 | 24 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | NA |