論文 - 詳細
| RRC ID | 16047 |
|---|---|
| 著者 | Fujii T, Fujii T, Namiki S, Abe H, Sakurai T, Ohnuma A, Kanzaki R, Katsuma S, Ishikawa Y, Shimada T. |
| タイトル | Sex-linked transcription factor involved in a shift of sex-pheromone preference in the silkmoth Bombyx mori. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
In the sex-pheromone communication systems of moths, odorant receptor (Or) specificity as well as higher olfactory information processing in males should be finely tuned to the pheromone of conspecific females. Accordingly, male sex-pheromone preference should have diversified along with the diversification of female sex pheromones; however, the genetic mechanisms that facilitated the diversification of male preference are not well understood. Here, we explored the mechanisms involved in a drastic shift in sex-pheromone preference in the silkmoth Bombyx mori using spli mutants in which the genomic structure of the gene Bmacj6, which encodes a class IV POU domain transcription factor, is disrupted or its expression is repressed. B. mori females secrete an ∼11:1 mixture of bombykol and bombykal. Bombykol alone elicits full male courtship behavior, whereas bombykal alone shows no apparent activity. In the spli mutants, the behavioral responsiveness of males to bombykol was markedly reduced, whereas bombykal alone evoked full courtship behavior. The reduced response of spli males to bombykol was explained by the paucity of bombykol receptors on the male antennae. It was also found that, in the spli males, neurons projecting into the toroid, a compartment in the brain where bombykol receptor neurons normally project, responded strongly to bombykal. The present study highlights a POU domain transcription factor, Bmacj6, which may have caused a shift of sex-pheromone preference in B. mori through Or gene choice and/or axon targeting. |
| 巻・号 | 108(44) |
| ページ | 18038-43 |
| 公開日 | 2011-11-1 |
| DOI | 10.1073/pnas.1107282108 |
| PII | 1107282108 |
| 解説 | spli(エスプリ）の原因遺伝子はBmacj6である。Bmacj6はPOUドメインを持った転写因子をコードする。n41系統(spli/spli)のZ染色体は二つに切断されており、切断によって、Bmacj6のエクソン2～4が欠失している。 |
| PMID | 22006327 |
| PMC | PMC3207681 |
| MeSH | Alleles Animals Bombyx / genetics Bombyx / metabolism* Bombyx / physiology Female Male Molecular Sequence Data Odorants Sex Attractants* Sex Factors* Sexual Behavior, Animal* Transcription Factors / metabolism* |
| IF | 9.412 |
| 引用数 | 20 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| カイコ | n41 |