RRC ID 1621
Author Jordan IK, Rogozin IB, Wolf YI, Koonin EV.
Title Essential genes are more evolutionarily conserved than are nonessential genes in bacteria.
Journal Genome Res.
Abstract The "knockout-rate" prediction holds that essential genes should be more evolutionarily conserved than are nonessential genes. This is because negative (purifying) selection acting on essential genes is expected to be more stringent than that for nonessential genes, which are more functionally dispensable and/or redundant. However, a recent survey of evolutionary distances between Saccharomyces cerevisiae and Caenorhabditis elegans proteins did not reveal any difference between the rates of evolution for essential and nonessential genes. An analysis of mouse and rat orthologous genes also found that essential and nonessential genes evolved at similar rates when genes thought to evolve under directional selection were excluded from the analysis. In the present study, we combine genomic sequence data with experimental knockout data to compare the rates of evolution and the levels of selection for essential versus nonessential bacterial genes. In contrast to the results obtained for eukaryotic genes, essential bacterial genes appear to be more conserved than are nonessential genes over both relatively short (microevolutionary) and longer (macroevolutionary) time scales.
Volume 12(6)
Pages 962-8
Published 2002-6
DOI 10.1101/gr.87702
PMID 12045149
PMC PMC1383730
MeSH Conserved Sequence / genetics* Escherichia coli / genetics Evolution, Molecular* Genes, Bacterial / genetics* Genes, Essential / genetics* Genome, Bacterial Gram-Negative Bacteria / genetics* Helicobacter pylori / genetics Neisseria meningitidis / genetics
IF 9.944
Times Cited 292
WOS Category BIOTECHNOLOGY & APPLIED MICROBIOLOGY GENETICS & HEREDITY BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
INFORMATION E.coli