| RRC ID |
1621
|
| 著者 |
Jordan IK, Rogozin IB, Wolf YI, Koonin EV.
|
| タイトル |
Essential genes are more evolutionarily conserved than are nonessential genes in bacteria.
|
| ジャーナル |
Genome Res
|
| Abstract |
The "knockout-rate" prediction holds that essential genes should be more evolutionarily conserved than are nonessential genes. This is because negative (purifying) selection acting on essential genes is expected to be more stringent than that for nonessential genes, which are more functionally dispensable and/or redundant. However, a recent survey of evolutionary distances between Saccharomyces cerevisiae and Caenorhabditis elegans proteins did not reveal any difference between the rates of evolution for essential and nonessential genes. An analysis of mouse and rat orthologous genes also found that essential and nonessential genes evolved at similar rates when genes thought to evolve under directional selection were excluded from the analysis. In the present study, we combine genomic sequence data with experimental knockout data to compare the rates of evolution and the levels of selection for essential versus nonessential bacterial genes. In contrast to the results obtained for eukaryotic genes, essential bacterial genes appear to be more conserved than are nonessential genes over both relatively short (microevolutionary) and longer (macroevolutionary) time scales.
|
| 巻・号 |
12(6)
|
| ページ |
962-8
|
| 公開日 |
2002-6-1
|
| DOI |
10.1101/gr.87702
|
| PMID |
12045149
|
| PMC |
PMC1383730
|
| MeSH |
Conserved Sequence / genetics*
Escherichia coli / genetics
Evolution, Molecular*
Genes, Bacterial / genetics*
Genes, Essential / genetics*
Genome, Bacterial
Gram-Negative Bacteria / genetics*
Helicobacter pylori / genetics
Neisseria meningitidis / genetics
|
| IF |
11.093
|
| 引用数 |
364
|
|
WOS 分野
|
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
GENETICS & HEREDITY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| 情報 |
E.coli |
