Reference - Detail
| RRC ID | 1637 |
|---|---|
| Author | Rocha EP, Danchin A. |
| Title | Essentiality, not expressiveness, drives gene-strand bias in bacteria. |
| Journal | Nat Genet |
| Abstract |
Preferential positioning of bacterial genes in the leading strand was thought to result from selection to avoid high head-on collision rates between DNA and RNA polymerases. Here we show, however, that in Bacillus subtilis and Escherichia coli, essentiality (the transcript product), not expressiveness (the collision rate), selectively drives the biased gene distribution. |
| Volume | 34(4) |
| Pages | 377-8 |
| Published | 2003-8-1 |
| DOI | 10.1038/ng1209 |
| PII | ng1209 |
| PMID | 12847524 |
| MeSH | Bacillus subtilis / genetics* Bacillus subtilis / metabolism DNA Replication DNA-Directed DNA Polymerase / metabolism DNA-Directed RNA Polymerases / metabolism Escherichia coli / genetics* Escherichia coli / metabolism Gene Expression Genes, Bacterial* Transcription, Genetic |
| IF | 27.605 |
| Times Cited | 149 |
| WOS Category | GENETICS & HEREDITY |
| Resource | |
| INFORMATION | E.coli |