RRC ID 1637
著者 Rocha EP, Danchin A.
タイトル Essentiality, not expressiveness, drives gene-strand bias in bacteria.
ジャーナル Nat Genet
Abstract Preferential positioning of bacterial genes in the leading strand was thought to result from selection to avoid high head-on collision rates between DNA and RNA polymerases. Here we show, however, that in Bacillus subtilis and Escherichia coli, essentiality (the transcript product), not expressiveness (the collision rate), selectively drives the biased gene distribution.
巻・号 34(4)
ページ 377-8
公開日 2003-8-1
DOI 10.1038/ng1209
PII ng1209
PMID 12847524
MeSH Bacillus subtilis / genetics* Bacillus subtilis / metabolism DNA Replication DNA-Directed DNA Polymerase / metabolism DNA-Directed RNA Polymerases / metabolism Escherichia coli / genetics* Escherichia coli / metabolism Gene Expression Genes, Bacterial* Transcription, Genetic
IF 27.605
引用数 149
WOS 分野 GENETICS & HEREDITY
リソース情報
情報 E.coli