論文 - 詳細
RRC ID | 1637 |
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著者 | Rocha EP, Danchin A. |
タイトル | Essentiality, not expressiveness, drives gene-strand bias in bacteria. |
ジャーナル | Nat Genet |
Abstract |
Preferential positioning of bacterial genes in the leading strand was thought to result from selection to avoid high head-on collision rates between DNA and RNA polymerases. Here we show, however, that in Bacillus subtilis and Escherichia coli, essentiality (the transcript product), not expressiveness (the collision rate), selectively drives the biased gene distribution. |
巻・号 | 34(4) |
ページ | 377-8 |
公開日 | 2003-8-1 |
DOI | 10.1038/ng1209 |
PII | ng1209 |
PMID | 12847524 |
MeSH | Bacillus subtilis / genetics* Bacillus subtilis / metabolism DNA Replication DNA-Directed DNA Polymerase / metabolism DNA-Directed RNA Polymerases / metabolism Escherichia coli / genetics* Escherichia coli / metabolism Gene Expression Genes, Bacterial* Transcription, Genetic |
IF | 27.605 |
引用数 | 149 |
WOS 分野 | GENETICS & HEREDITY |
リソース情報 | |
情報 | E.coli |