RRC ID 166
Author Kuramoto T, Gohma H, Kimura K, Wedekind D, Hedrich HJ, Serikawa T.
Title The rat pink-eyed dilution (p) mutation: an identical intragenic deletion in pink-eye dilute-coat strains and several Wistar-derived albino strains.
Journal Mamm. Genome
Abstract We identified the rat pink-eyed dilution (p) and pink eye Mishima (p(m)) mutations. The p(m) mutation, which was isolated from a wild rat caught in Mishima Japan in 1961 and is carried in the NIG-III strain, is a splice donor site mutation in intron 5. The p mutation, which was first described in 1914 and is carried in several p/p rats including the RCS and BDV strains, is an intragenic deletion including exons 17 and 18. In addition to RCS and BDV strains, several albino strains, KHR, KMI and WNA, all descendants of albino stock of the Wistar Institute, are homozygous for the p allele. Analyses revealed that the colored p strains and the Wistar-derived albino p strains had the same marker haplotype spanning approximately 4 Mb around the P locus. This indicates that these p strains share a common ancestor and the p allele did not arise independently via recurrent mutations. The historical relationship among the p strains suggests that the p deletion had been maintained in stock heterogeneous for the C and P loci and then was inherited independently by the ancestor of the Wistar albino stock and the ancestor of the pink-eyed agouti rats in Europe.
Volume 16(9)
Pages 712-9
Published 2005-9
DOI 10.1007/s00335-005-0061-8
PMID 16245028
MeSH Albinism / genetics* Animals Base Sequence DNA Primers Gene Components Gene Deletion* Haplotypes / genetics Japan Membrane Transport Proteins / genetics* Microsatellite Repeats / genetics Molecular Sequence Data Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA
IF 2.687
Times Cited 1
Rats ACI/NKyo(strainID=6) WTC/Kyo(strainID=18) KHR/Kyo(strainID=4) KMI/Tky(strainID=29) NIG-III/Hok(strainID=73) RCS/Kyo(strainID=27) WNA/Nshm(strainID=149)