| RRC ID |
166
|
| 著者 |
Kuramoto T, Gohma H, Kimura K, Wedekind D, Hedrich HJ, Serikawa T.
|
| タイトル |
The rat pink-eyed dilution (p) mutation: an identical intragenic deletion in pink-eye dilute-coat strains and several Wistar-derived albino strains.
|
| ジャーナル |
Mamm Genome
|
| Abstract |
We identified the rat pink-eyed dilution (p) and pink eye Mishima (p(m)) mutations. The p(m) mutation, which was isolated from a wild rat caught in Mishima Japan in 1961 and is carried in the NIG-III strain, is a splice donor site mutation in intron 5. The p mutation, which was first described in 1914 and is carried in several p/p rats including the RCS and BDV strains, is an intragenic deletion including exons 17 and 18. In addition to RCS and BDV strains, several albino strains, KHR, KMI and WNA, all descendants of albino stock of the Wistar Institute, are homozygous for the p allele. Analyses revealed that the colored p strains and the Wistar-derived albino p strains had the same marker haplotype spanning approximately 4 Mb around the P locus. This indicates that these p strains share a common ancestor and the p allele did not arise independently via recurrent mutations. The historical relationship among the p strains suggests that the p deletion had been maintained in stock heterogeneous for the C and P loci and then was inherited independently by the ancestor of the Wistar albino stock and the ancestor of the pink-eyed agouti rats in Europe.
|
| 巻・号 |
16(9)
|
| ページ |
712-9
|
| 公開日 |
2005-9-1
|
| DOI |
10.1007/s00335-005-0061-8
|
| PMID |
16245028
|
| MeSH |
Albinism / genetics*
Animals
Base Sequence
DNA Primers
Gene Components
Gene Deletion*
Haplotypes / genetics
Japan
Membrane Transport Proteins / genetics*
Microsatellite Repeats / genetics
Molecular Sequence Data
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA
|
| IF |
2.287
|
| 引用数 |
2
|
|
WOS 分野
|
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
GENETICS & HEREDITY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ラット |
ACI/NKyo(strainID=6)
WTC/Kyo(strainID=18)
KHR/Kyo(strainID=4)
KMI/Tky(strainID=29)
NIG-III/Hok(strainID=73)
RCS/Kyo(strainID=27)
WNA/Nshm(strainID=149) |
