| RRC ID |
170
|
| 著者 |
Liu Y, Imai H, Sadamatsu M, Tsunashima K, Kato N.
|
| タイトル |
Cytokines participate in neuronal death induced by trimethyltin in the rat hippocampus via type II glucocorticoid receptors.
|
| ジャーナル |
Neurosci Res
|
| Abstract |
We investigated the role of IL-1alpha and IL-1beta expressed in the reactive gliosis following hippocampal damage induced by trimethyltin (TMT). IL-1alpha immunoreactivity was expressed earlier in small glial cells on day 4 post-TMT, while IL-1beta expression was obvious in large swollen glial cells on day 14 post-TMT. Both IL-1alpha and IL-1beta immunoreactivities were double-labeled with astrocyte marker, vimentin, but not with a microglia marker, OX-42. The expression of both IL-1alpha/beta was enhanced by adrenalectomy (ADX) prior to TMT administration. Corticosterone (CORT) or dexamethasone (DEX) supplementation not only cancelled effects of ADX, but also partially reversed TMT-induced enhancement of IL-1alpha/beta expressions. These changes coincided with TMT-induced neuronal death in CA3 pyramidal cells of the hippocampus. It is suggested that IL-1alpha/beta expressed in reactive astrocytes participate in TMT neurotoxicity via type II glucocorticoid receptors.
|
| 巻・号 |
51(3)
|
| ページ |
319-27
|
| 公開日 |
2005-3-1
|
| DOI |
10.1016/j.neures.2004.12.005
|
| PII |
S0168-0102(04)00309-8
|
| PMID |
15773051
|
| MeSH |
Adrenalectomy
Animals
Anti-Inflammatory Agents / pharmacology
Cell Death / drug effects
Cell Death / physiology*
Cortisone / pharmacology
Cytokines / drug effects
Cytokines / metabolism*
Dexamethasone / pharmacology
Gliosis / chemically induced
Hippocampus / drug effects
Hippocampus / pathology*
Image Processing, Computer-Assisted
Immunohistochemistry
Infusion Pumps, Implantable
Male
Microscopy, Confocal
Neuroglia / drug effects
Neuroglia / metabolism
Neurons / drug effects
Neurons / pathology*
Rats
Receptors, Glucocorticoid / drug effects
Receptors, Glucocorticoid / metabolism*
Receptors, Glucocorticoid / physiology*
Trimethyltin Compounds / toxicity*
|
| IF |
2.645
|
| 引用数 |
23
|
| リソース情報 |
| ラット |
|
