RRC ID 17439
著者 Sakagami H, Amano S, Kikuchi H, Nakamura Y, Kuroshita R, Watanabe S, Satoh K, Hasegawa H, Nomura A, Kanamoto T, Terakubo S, Nakashima H, Taniguchi S, Oizumi T.
タイトル Antiviral, antibacterial and vitamin C-synergized radical-scavenging activity of Sasa senanensis Rehder extract.
ジャーナル In Vivo
Abstract Sasa senanensis Rehder extract (SE) showed slightly higher cytotoxicity against human squamous cell carcinoma cell lines and human glioblastoma cell lines, as compared with human oral normal cells (gingival fibroblast, pulp cell, periodontal ligament fibroblast), and was more cytotoxic to human myelogenous and T-cell leukemia cell lines. SE showed a bacteriostatic effect on Fusobacterium nucleatum and Prevotella intermedia, but almost completely eliminated hydrogen sulfide (H2S) and methyl mercaptan (CH3SH) produced by these bacteria. SE protected human T-cell leukemia MT-4 cells from the cytopathic effect of human immunodeficiency virus (HIV) infection, and its anti-HIV activity was much higher than that of tannins and flavonoids, comparable with that of natural and synthetic lignins. SE also protected the MDCK cells from the cytopathic effect of influenza virus infection. SE synergistically enhanced the superoxide anion and hydroxyl radical-scavenging activity of vitamin C. The present study suggests the functionality of SE as a complementary alternative medicine.
巻・号 22(4)
ページ 471-6
公開日 2008-1-1
PMID 18712174
MeSH Animals Anti-Bacterial Agents / pharmacology* Anti-HIV Agents / pharmacology Antiviral Agents / pharmacology* Ascorbic Acid / metabolism* Ascorbic Acid / pharmacology* Cell Line Cell Line, Tumor Dogs Drug Synergism Fibroblasts / metabolism Free Radical Scavengers / pharmacology HIV Infections / prevention & control Humans Plant Extracts / pharmacology* Sasa / metabolism*
IF 1.541
引用数 28
WOS 分野 MEDICINE, RESEARCH & EXPERIMENTAL
リソース情報
一般微生物 JCM 12248