Reference - Detail
| RRC ID | 17479 |
|---|---|
| Author | Allard P, Colaiácovo MP. |
| Title | Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities. |
| Journal | Proc Natl Acad Sci U S A |
| Abstract |
Bisphenol A (BPA) is a highly prevalent constituent of plastics that has been associated with diabetes, cardiovascular disease, and an increased risk of miscarriages in humans. In mice, BPA exposure disrupts the process of meiosis; however, analysis of the affected molecular pathways is lagging and has been particularly challenging. Here we show that exposure of the nematode Caenorhabditis elegans to BPA, at internal concentrations consistent with mammalian models, causes increased sterility and embryonic lethality. BPA exposure results in impaired chromosome synapsis and disruption of meiotic double-strand break repair (DSBR) progression. BPA carries an anti-estrogenic activity in the germline and results in germline-specific down-regulation of DSBR genes, thereby impairing maintenance of genomic integrity during meiosis. C. elegans therefore constitutes a model of remarkable relevance to mammals with which to assess how our chemical landscape affects germ cells and meiosis. |
| Volume | 107(47) |
| Pages | 20405-10 |
| Published | 2010-11-23 |
| DOI | 10.1073/pnas.1010386107 |
| PII | 1010386107 |
| PMID | 21059909 |
| PMC | PMC2996676 |
| MeSH | Animals Benzhydryl Compounds Caenorhabditis elegans Chromatography, Liquid Chromosome Aberrations / drug effects* Chromosome Segregation / drug effects DNA Breaks, Double-Stranded / drug effects* DNA Repair / drug effects* Environmental Pollutants / pharmacokinetics Environmental Pollutants / toxicity* Fluorescent Antibody Technique Germ-Line Mutation / drug effects* Indoles Models, Animal* Phenols / pharmacokinetics Phenols / toxicity* Reverse Transcriptase Polymerase Chain Reaction Statistics, Nonparametric Tandem Mass Spectrometry |
| IF | 9.412 |
| Times Cited | 89 |
| WOS Category | GENETICS & HEREDITY |
| Resource | |
| C.elegans | tm1473 |