Reference - Detail
| RRC ID | 17493 |
|---|---|
| Author | Christensen JE, Fenger C, Issazadeh-Navikas S, Krug A, Liljestrøm P, Goriely S, Paludan SR, Finsen B, Christensen JP, Thomsen AR. |
| Title | Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic choriomeningitis virus-infected central nervous system versus the periphery. |
| Journal | J Virol |
| Abstract |
Interferon (IFN) regulatory factors (IRFs) are a family of transcription factors involved in regulating type I IFN genes and other genes participating in the early antiviral host response. To better understand the mechanisms involved in virus-induced central nervous system (CNS) inflammation, we studied the influence of IRF1, -3, -7, and -9 on the transcriptional activity of key genes encoding antiviral host factors in the CNS of mice infected with lymphocytic choriomeningitis virus (LCMV). A key finding is that neither IRF3 nor IRF7 is absolutely required for induction of a type I IFN response in the LCMV-infected CNS, whereas concurrent elimination of both factors markedly reduces the virus-induced host response. This is unlike the situation in the periphery, where deficiency of IRF7 almost eliminates the LCMV-induced production of the type I IFNs. This difference is seemingly related to the local environment, as peripheral production of type I IFNs is severely reduced in intracerebrally (i.c.) infected IRF7-deficient mice, which undergo a combined infection of the CNS and peripheral organs, such as spleen and lymph nodes. Interestingly, despite the redundancy of IRF7 in initiating the type I IFN response in the CNS, the response is not abolished in IFN-β-deficient mice, as might have been expected. Collectively, these data demonstrate that the early type I IFN response to LCMV infection in the CNS is controlled by a concerted action of IRF3 and -7. Consequently this work provides strong evidence for differential regulation of the type I IFN response in the CNS versus the periphery during viral infection. |
| Volume | 86(13) |
| Pages | 7384-92 |
| Published | 2012-7-1 |
| DOI | 10.1128/JVI.07090-11 |
| PII | JVI.07090-11 |
| PMID | 22514347 |
| PMC | PMC3416342 |
| MeSH | Animals Female Interferon Regulatory Factor-3 / deficiency Interferon Regulatory Factor-3 / immunology* Interferon Regulatory Factor-3 / metabolism Interferon Regulatory Factor-7 / deficiency Interferon Regulatory Factor-7 / immunology* Interferon Regulatory Factor-7 / metabolism Interferon Type I / biosynthesis* Lymphocytic choriomeningitis virus / immunology* Male Mice Mice, Inbred C57BL Nervous System / immunology* Nervous System / virology* |
| IF | 4.501 |
| Times Cited | 14 |
| WOS Category | VIROLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC00858 RBRC01420 |