Reference - Detail
| RRC ID | 17501 |
|---|---|
| Author | Kawamoto S, Tran TH, Maruya M, Suzuki K, Doi Y, Tsutsui Y, Kato LM, Fagarasan S. |
| Title | The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. |
| Journal | Science |
| Abstract |
Immunoglobulin A (IgA) is essential to maintain the symbiotic balance between gut bacterial communities and the host immune system. Here we provide evidence that the inhibitory co-receptor programmed cell death-1 (PD-1) regulates the gut microbiota through appropriate selection of IgA plasma cell repertoires. PD-1 deficiency generates an excess number of T follicular helper (T(FH)) cells with altered phenotypes, which results in dysregulated selection of IgA precursor cells in the germinal center of Peyer's patches. Consequently, the IgAs produced in PD-1-deficient mice have reduced bacteria-binding capacity, which causes alterations of microbial communities in the gut. Thus, PD-1 plays a critical role in regulation of antibody diversification required for the maintenance of intact mucosal barrier. |
| Volume | 336(6080) |
| Pages | 485-9 |
| Published | 2012-4-27 |
| DOI | 10.1126/science.1217718 |
| PII | 336/6080/485 |
| PMID | 22539724 |
| MeSH | Adoptive Transfer Animals B-Lymphocytes / immunology* Bacteria / immunology Bacterial Load Bacterial Physiological Phenomena* Feces / microbiology Genes, Immunoglobulin Heavy Chain Germinal Center / cytology Germinal Center / immunology Immunoglobulin A / biosynthesis Immunoglobulin A / immunology* Intestinal Mucosa / immunology* Intestine, Small / immunology Intestine, Small / microbiology* Lymphocyte Count Mice Peyer's Patches / cytology Peyer's Patches / immunology Plasma Cells / immunology Plasma Cells / physiology Programmed Cell Death 1 Receptor / genetics Programmed Cell Death 1 Receptor / physiology* Symbiosis T-Lymphocytes, Helper-Inducer / immunology* |
| IF | 41.846 |
| Times Cited | 230 |
| WOS Category | IMMUNOLOGY |
| Resource | |
| Mice | RBRC02142 |