Reference - Detail
| RRC ID | 17511 |
|---|---|
| Author | Kamo H, Honda K, Kitagawa J, Tsuboi Y, Kondo M, Taira M, Yamashita A, Katsuyama N, Masuda Y, Kato T, Iwata K. |
| Title | Topical capsaicin application causes cold hypersensitivity in awake monkeys. |
| Journal | J Oral Sci |
| Abstract |
Recent animal studies have demonstrated that many trigeminal ganglion neurons co-express TRPV1 and TRPA1 receptors following peripheral inflammation. In the present study, we examined whether cold receptors were sensitized by capsaicin in awake monkeys. Two monkeys were trained to detect a change in cold stimulus temperature (30 degrees C to 0.5, 1.0, 1.5 or 2.0 degrees C) applied to the facial skin. A total of 589 trials were studied, and the number of escape and hold-through trials and detection latency were measured. The number of escape trials was increased after capsaicin treatment, whereas that of hold-through trials was decreased. Detection latency was significantly decreased after capsaicin treatment. The present findings suggest that topical application of capsaicin to the facial skin induces reversible hypersensitivity to a facial cold stimulus in behaving monkeys. |
| Volume | 50(2) |
| Pages | 175-9 |
| Published | 2008-6-1 |
| DOI | 10.2334/josnusd.50.175 |
| PII | JST.JSTAGE/josnusd/50.175 |
| PMID | 18587207 |
| MeSH | Administration, Cutaneous Animals Capsaicin / administration & dosage Capsaicin / pharmacology* Cold Temperature* Face / innervation Macaca Reaction Time / drug effects Sensory System Agents / administration & dosage Sensory System Agents / pharmacology* Sensory Thresholds / drug effects* Skin / drug effects Skin / innervation TRPV Cation Channels / drug effects Thermoreceptors / drug effects* Wakefulness |
| IF | 1.2 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Japanese macaques | |