| RRC ID |
17585
|
| Author |
Sugimoto N, Iwaki T, Chardwiriyapreecha S, Shimazu M, Sekito T, Takegawa K, Kakinuma Y.
|
| Title |
Vba2p, a vacuolar membrane protein involved in basic amino acid transport in Schizosaccharomyces pombe.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
A recent study filling the gap in the genome sequence in the left arm of chromosome 2 of Schizosaccharomyces pombe revealed a homolog of budding yeast Vba2p, a vacuolar transporter of basic amino acids. GFP-tagged Vba2p in fission yeast was localized to the vacuolar membrane. Upon disruption of vba2, the uptake of several amino acids, including lysine, histidine, and arginine, was impaired. A transient increase in lysine uptake under nitrogen starvation was lowered by this mutation. These findings suggest that Vba2p is involved in basic amino acid transport in S. pombe under diverse conditions.
|
| Volume |
74(10)
|
| Pages |
2166-9
|
| Published |
2010-1-1
|
| DOI |
10.1271/bbb.100627
|
| PII |
JST.JSTAGE/bbb/100627
|
| PMID |
20944394
|
| MeSH |
Amino Acids, Basic / metabolism*
Biological Transport
Deoxyglucose / metabolism
Membrane Transport Proteins / metabolism*
Nitrogen / deficiency
Schizosaccharomyces / cytology
Schizosaccharomyces / metabolism*
Schizosaccharomyces pombe Proteins / metabolism*
|
| IF |
1.516
|
| Times Cited |
3
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Yeast |
plasmid |
