論文 - 詳細
| RRC ID | 17619 |
|---|---|
| 著者 | Kobayashi N, Saito T, Uematsu T, Kishi K, Toba M, Kohda N, Suzuki T. |
| タイトル | Oral administration of heat-killed Lactobacillus pentosus strain b240 augments protection against influenza virus infection in mice. |
| ジャーナル | Int Immunopharmacol |
| Abstract |
Host-defense mechanisms against influenza virus (IFV) infection involve both innate and acquired immunities. Among other components, secretory immunoglobulin A (SIgA) in the airway mucosa plays a particularly pivotal role in preventing IFV infection. Among 150 strains of lactic acid bacteria, Lactobacillus pentosus strain b240 (b240) has the highest IgA-inducing potency in mouse Peyer's patch cells. We previously reported a practical new finding that oral ingestion of nonviable heat-killed b240 elevates salivary IgA secretion in humans. The present study aimed to determine if nonviable b240 can prevent IFV infection in mice. In a BALB/c mouse model infected with lethal levels of IFV A/PR8/34 (H1N1), oral administration of b240 for 3 weeks by gavage prior to IFV infection significantly prolonged the survival period. For IFV infection at nonlethal levels, the infectious titers of IFV in the lungs 7 days after infection were significantly reduced after similar b240 administration. Both anti-IFV IgA and immunoglobulin G titers in bronchoalveolar lavage fluid and plasma on day 7 were significantly higher in the b240-treated group than the control group. The augmentation of the anti-IFV immune response by b240 application was preliminarily confirmed by the elevated production of IFV-driven T-cell factors during mixed lymphocyte reactions with b240-primed splenocytes. These results suggest that oral nonviable heat-killed b240 intake can facilitate protection against IFV infection. |
| 巻・号 | 11(2) |
| ページ | 199-203 |
| 公開日 | 2011-2-1 |
| DOI | 10.1016/j.intimp.2010.11.019 |
| PII | S1567-5769(10)00383-8 |
| PMID | 21095259 |
| MeSH | Administration, Oral Animals Cell Line Dogs Epithelial Cells / virology Female Hot Temperature* Immunity, Cellular / immunology Immunity, Mucosal / immunology Immunoglobulin A / blood Immunoglobulin G / blood Influenza A Virus, H1N1 Subtype* / pathogenicity Lactobacillus / immunology* Lung / immunology Lung / virology Lymphocytes / immunology Mice Mice, Inbred BALB C Orthomyxoviridae Infections / immunology Orthomyxoviridae Infections / prevention & control* |
| IF | 3.943 |
| 引用数 | 54 |
| WOS 分野 | PHARMACOLOGY & PHARMACY IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | CTLL-2(RCB0637) MDCK(RCB0995) |