論文 - 詳細
| RRC ID | 17636 |
|---|---|
| 著者 | Zhang D, Pan X, Ohno S, Osuga T, Sawada S, Sato K. |
| タイトル | No effects of pulsed electromagnetic fields on expression of cell adhesion molecules (integrin, CD44) and matrix metalloproteinase-2/9 in osteosarcoma cell lines. |
| ジャーナル | Bioelectromagnetics |
| Abstract |
Pulsed electromagnetic fields (PEMF) could enhance the cytocidal effects of chemotherapeutic drugs on malignant tumor cell lines, but metastasis effects of PEMF on tumor cells have not been investigated. We investigated the effects of PEMF exposure on the expression levels of some metastasis-related molecules, including integrin α subunits (α1, α2, α3, α4, α5, α6, αv), integrin β subunits (β1, β2, β3, β4), CD44, and matrix metalloproteinase-2/9 (MMP-2/9) in four human osteosarcoma cell lines (HOS, MG-63, SAOS-2, NY) and two mouse osteosarcoma cell lines (DOS, LM8) by using FACScan analysis, gelatin zymography, and Western blot analysis. Our results indicate that PEMF exposure has no effect on the expression of some molecules that are associated with tumor cell invasion and metastasis, and therefore suggest that PEMF exposure may be safely applied to chemotherapy for osteosarcoma. |
| 巻・号 | 32(6) |
| ページ | 463-73 |
| 公開日 | 2011-9-1 |
| DOI | 10.1002/bem.20647 |
| PMID | 21480303 |
| MeSH | Animals Bone Neoplasms / metabolism* Bone Neoplasms / pathology Bone Neoplasms / therapy Cell Adhesion Molecules / metabolism* Cell Line, Tumor Electromagnetic Fields* Humans Hyaluronan Receptors / metabolism Integrin alpha Chains / metabolism Integrin beta Chains / metabolism Magnetic Field Therapy Matrix Metalloproteinase 2 / metabolism Matrix Metalloproteinase 9 / metabolism Mice Osteosarcoma / metabolism* Osteosarcoma / pathology Osteosarcoma / therapy |
| IF | 2.278 |
| 引用数 | 6 |
| WOS 分野 | BIOLOGY BIOPHYSICS |
| リソース情報 | |
| ヒト・動物細胞 | LM8(RCB1450) |