| RRC ID |
17659
|
| 著者 |
Honami T, Shimo T, Okui T, Kurio N, Hassan NM, Iwamoto M, Sasaki A.
|
| タイトル |
Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction.
|
| ジャーナル |
Oral Oncol
|
| Abstract |
Sonic hedgehog (Shh) and its signaling have been identified in several human cancers, and increased levels of its expression appear to correlate with disease progression and metastasis. However, the role of Shh in bone destruction associated with oral squamous cell carcinomas, which frequently invade the maxilla or the mandible, is still unclear. In this study we show that the use of siRNA for Shh to block SHH secreted by SAS oral squamous cell carcinoma cells suppressed the tumor growth and tumor angiogenesis of subcutaneous SAS xenografts in vivo. Moreover, blockade of Shh in SAS cells decreased tumor growth and osteoclast number in a tibial metaphysis mouse model. Significantly, we clearly show that SHH stimulated osteoclast formation in a co-culture system consisting of murine bone stromal ST2 cells and murine CD11b(+) bone marrow cells. These findings suggest that Shh signaling is a potential target for the treatment of oral squamous cell carcinoma associated with bone destruction.
|
| 巻・号 |
48(1)
|
| ページ |
49-55
|
| 公開日 |
2012-1-1
|
| DOI |
10.1016/j.oraloncology.2011.08.026
|
| PII |
S1368-8375(11)00815-3
|
| PMID |
21945071
|
| MeSH |
Animals
Bone Marrow Cells / cytology
Bone Marrow Cells / metabolism
Bone Neoplasms / metabolism*
Bone Neoplasms / pathology
Bone Resorption / metabolism*
Bone Resorption / pathology
CD11b Antigen
Carcinoma, Squamous Cell / metabolism*
Carcinoma, Squamous Cell / pathology
Female
Hedgehog Proteins / metabolism*
Humans
Mice
Mice, Inbred BALB C
Mice, Nude
Mouth Neoplasms / metabolism*
Mouth Neoplasms / pathology
Neoplasms, Experimental
RNA, Small Interfering
Reverse Transcriptase Polymerase Chain Reaction
Stromal Cells / cytology
Stromal Cells / metabolism
Tibia / pathology*
|
| IF |
3.979
|
| 引用数 |
15
|
|
WOS 分野
|
DENTISTRY, ORAL SURGERY & MEDICINE
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
ST2(RCB0224) |
