Reference - Detail
| RRC ID | 17668 |
|---|---|
| Author | Takai N, Ueda T, Ishii T, Kira N, Nishida M, Nasu K, Narahara H. |
| Title | Erucylphosphocholine induces growth inhibition, cell cycle arrest, and apoptosis in human choriocarcinoma cells. |
| Journal | Tumour Biol |
| Abstract |
A membrane-targeted, lipophilic ether lipid of synthetic phospholipid analog, erucylphosphocholine (ErPC), induces apoptosis in some lines of human tumor cells. We investigated the effect of ErPC in the choriocarcinoma cell line, BeWo. BeWo cells were treated with various concentrations of ErPC, and changes in cell growth, the cell cycle, apoptosis, and related parameters were examined. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that BeWo cells were sensitive to the growth inhibitory effect of ErPC. Cell cycle analysis indicated that exposure to ErPC decreased the proportion of cells in the S phase and increased the proportion in the G0/G1 phases of the cell cycle. Induction of apoptosis was confirmed by Annexin V staining of externalized phosphatidylserine and by the loss of mitochondrial transmembrane potential. This induction occurred in conjunction with the altered expression of genes related to cell growth, malignant phenotype, and apoptosis. These results suggest that ErPC may serve as a therapeutic agent for the treatment of choriocarcinoma. |
| Volume | 32(3) |
| Pages | 569-74 |
| Published | 2011-6-1 |
| DOI | 10.1007/s13277-010-0152-3 |
| PMID | 21213097 |
| MeSH | Apoptosis / drug effects* Cell Cycle / drug effects* Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Choriocarcinoma / drug therapy* Choriocarcinoma / pathology Female Humans Membrane Potential, Mitochondrial / drug effects Phosphorylcholine / analogs & derivatives* Phosphorylcholine / pharmacology Pregnancy Uterine Neoplasms / drug therapy* Uterine Neoplasms / pathology |
| IF | 3.65 |
| Times Cited | 3 |
| WOS Category | ONCOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Blogs |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | BeWo(RCB1644) |