論文 - 詳細
| RRC ID | 17683 |
|---|---|
| 著者 | Hagiwara K, Goto T, Araki M, Miyazaki H, Hagiwara H. |
| タイトル | Olive polyphenol hydroxytyrosol prevents bone loss. |
| ジャーナル | Eur J Pharmacol |
| Abstract |
Polyphenols reportedly exert physiological effects against diseases such as cancer, arteriosclerosis, hyperlipidemia and osteoporosis. The present study was designed to evaluate the effects of oleuropein, hydroxytyrosol and tyrosol, the major polyphenols in olives, on bone formation using cultured osteoblasts and osteoclasts, and on bone loss in ovariectomized mice. No polyphenols markedly affected the proliferation of osteoblastic MC3T3-E1 cells at concentrations up to 10μM. Oleuropein and hydroxytyrosol at 10 to 100μM had no effect on the production of type I collagen and the activity of alkaline phosphatase in MC3T3-E1 cells, but stimulated the deposition of calcium in a dose-dependent manner. In contrast, oleuropein at 10 to 100μM and hydroxytyrosol at 50 to 100μM inhibited the formation of multinucleated osteoclasts in a dose-dependent manner. Furthermore, both compounds suppressed the bone loss of trabecular bone in femurs of ovariectomized mice (6-week-old BALB/c female mice), while hydroxytyrosol attenuated H(2)O(2) levels in MC3T3-E1 cells. Our findings indicate that the olive polyphenols oleuropein and hydroxytyrosol may have critical effects on the formation and maintenance of bone, and can be used as effective remedies in the treatment of osteoporosis symptoms. |
| 巻・号 | 662(1-3) |
| ページ | 78-84 |
| 公開日 | 2011-7-15 |
| DOI | 10.1016/j.ejphar.2011.04.023 |
| PII | S0014-2999(11)00413-4 |
| PMID | 21539839 |
| MeSH | 3T3 Cells Animals Female Flavonoids / pharmacology* Flavonoids / therapeutic use Humans Iridoid Glucosides Iridoids Male Mice Olea / chemistry* Osteoblasts / cytology Osteoblasts / drug effects Osteoclasts / cytology Osteoclasts / drug effects Osteogenesis / drug effects Osteoporosis / drug therapy Osteoporosis / physiopathology Osteoporosis / prevention & control* Ovariectomy Phenols / pharmacology* Phenols / therapeutic use Phenylethyl Alcohol / analogs & derivatives* Phenylethyl Alcohol / pharmacology Phenylethyl Alcohol / therapeutic use Polyphenols Pyrans / pharmacology Pyrans / therapeutic use |
| IF | 3.263 |
| 引用数 | 78 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Google+ |
| 各媒体での言及数の合計 | 58 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |