論文 - 詳細
| RRC ID | 1769 |
|---|---|
| 著者 | Oka A, Aoto T, Totsuka Y, Takahashi R, Ueda M, Mita A, Sakurai-Yamatani N, Yamamoto H, Kuriki S, Takagi N, Moriwaki K, Shiroishi T. |
| タイトル | Disruption of genetic interaction between two autosomal regions and the X chromosome causes reproductive isolation between mouse strains derived from different subspecies. |
| ジャーナル | Genetics |
| Abstract |
Reproductive isolation that initiates speciation is likely caused by incompatibility among multiple loci in organisms belonging to genetically diverging populations. Laboratory C57BL/6J mice, which predominantly originated from Mus musculus domesticus, and a MSM/Ms strain derived from Japanese wild mice (M. m. molossinus, genetically close to M. m. musculus) are reproductively isolated. Their F1 hybrids are fertile, but successive intercrosses result in sterility. A consomic strain, C57BL/6J-ChrX(MSM), which carries the X chromosome of MSM/Ms in the C57BL/6J background, shows male sterility, suggesting a genetic incompatibility of the MSM/Ms X chromosome and other C57BL/6J chromosome(s). In this study, we conducted genomewide linkage analysis and subsequent QTL analysis using the sperm shape anomaly that is the major cause of the sterility of the C57BL/6J-ChrX(MSM) males. These analyses successfully detected significant QTL on chromosomes 1 and 11 that interact with the X chromosome. The introduction of MSM/Ms chromosomes 1 and 11 into the C57BL/6J-ChrX(MSM) background failed to restore the sperm-head shape, but did partially restore fertility. This result suggests that this genetic interaction may play a crucial role in the reproductive isolation between the two strains. A detailed analysis of the male sterility by intracytoplasmic sperm injection and zona-free in vitro fertilization demonstrated that the C57BL/6J-ChrX(MSM) spermatozoa have a defect in penetration through the zona pellucida of eggs. |
| 巻・号 | 175(1) |
| ページ | 185-97 |
| 公開日 | 2007-1-1 |
| DOI | 10.1534/genetics.106.062976 |
| PII | genetics.106.062976 |
| PMID | 17057240 |
| PMC | PMC1775014 |
| MeSH | Animals Crosses, Genetic Female Fertilization in Vitro Genetic Linkage Genotype Hybridization, Genetic* Inbreeding Male Mice / classification* Mice / genetics Mice, Inbred C57BL Quantitative Trait Loci Reproduction* Testis / physiology* X Chromosome* Y Chromosome / genetics |
| IF | 4.015 |
| 引用数 | 56 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 情報 | Mouse |